Pard6b par-6 family cell polarity regulator beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pard6bprovided by MGI
Official Full Name: par-6 family cell polarity regulator betaprovided by MGI
Primary source: MGI:MGI:2135605
See related: Ensembl:ENSMUSG00000044641 AllianceGenome:MGI:2135605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Par6b
Summary: Predicted to enable protein kinase C binding activity. Predicted to be involved in several processes, including centrosome cycle; establishment or maintenance of cell polarity; and protein-containing complex assembly. Predicted to act upstream of or within cell division. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and cell cortex. Is expressed in blastocyst; early conceptus; egg cylinder; and lung epithelium. Orthologous to human PARD6B (par-6 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 10.3), kidney adult (RPKM 8.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 88.24 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167922924..167943123)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (168081004..168101203)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42.
Title: Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.
Pard6b is necessary for blastocyst morphogenesis
Title: Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.
mPARD6b is the first identified protein to localize to the animal pole of the mouse oocyte and likely contributes to the polarization of the cortex.
Title: Two PAR6 proteins become asymmetrically localized during establishment of polarity in mouse oocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV025615 (e-PCR)
- UniSTS:164191

NoName (e-PCR)
- UniSTS:234611

D2Mit111 (e-PCR), detects polymorphism
- UniSTS:128970

Pard6b (e-PCR), detects polymorphism
- UniSTS:499187

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: partitioning defective 6 homolog beta

Names: PAR-6 beta; PAR-6B; par-6 (partitioning defective 6) homolog beta; partitioning-defective protein 6, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021409.2 → NP_067384.2 partitioning defective 6 homolog beta

See identical proteins and their annotated locations for NP_067384.2

Status: VALIDATED

Source sequence(s)

AI837082, AL831766, CJ050007, CJ062867, CX568497

Consensus CDS

CCDS17108.1

UniProtKB/Swiss-Prot

A2ANX8, Q8R3J8, Q9JK83

Related

ENSMUSP00000052619.7, ENSMUST00000052125.7

Conserved Domains (2) summary

cd06403
Location:17 → 96

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:156 → 247

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...