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ARHGAP22 Rho GTPase activating protein 22 [ Homo sapiens (human) ]

Gene ID: 58504, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGAP22provided by HGNC
Official Full Name
Rho GTPase activating protein 22provided by HGNC
Primary source
HGNC:HGNC:30320
See related
Ensembl:ENSG00000128805 MIM:610585; AllianceGenome:HGNC:30320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RhoGAP2; RhoGap22
Summary
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
10q11.22-q11.23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48429831..48656265, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49275552..49505563, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49654079..49864310, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:49394772-49395971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49397051-49398006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3329 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49441449-49441950 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49450548-49450771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:49455107-49455608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49495838-49496338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2355 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 12210 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:49607374-49608116 Neighboring gene Sharpr-MPRA regulatory region 2186 Neighboring gene Sharpr-MPRA regulatory region 5880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49653211-49654112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49662087-49663064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49668057-49668559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49671373-49672306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49672307-49673238 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49674919-49675115 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49678026-49678908 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49686951-49687608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49687609-49688265 Neighboring gene Sharpr-MPRA regulatory region 14185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49716013-49716998 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49725473-49726106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727221-49727810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727811-49728398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2356 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49741600-49742140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49750999-49751784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49763487-49763987 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49782573-49783074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3331 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49802653-49803477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49807300-49807800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49812539-49813269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49887725-49887989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49893168-49893708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49953319-49953863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3340 Neighboring gene WDFY family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3341 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3343 Neighboring gene uncharacterized LOC105378299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells. Mori M, et al. Anticancer Res, 2022 Dec. PMID 36456117
  2. Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy. Li R, et al. J Gene Med, 2017 Jun. PMID 28544509
  3. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin. Rowland AF, et al. Mol Cell Biol, 2011 Dec. PMID 21969604, Free PMC Article
  4. The molecular genetic architecture of self-employment. van der Loos MJ, et al. PLoS One, 2013. PMID 23593239, Free PMC Article
  5. The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. Hu SH, et al. PLoS One, 2012. PMID 22952583, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.
    Title: Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.
  2. DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
    Title: DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
  3. rs10491034 of gene ARHGAP22 is associated with diabetic retinopathy incidence and severity among Chinese Hui population.
    Title: Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
  4. There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population
    Title: Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy.
  5. a weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode
    Title: The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode.
  6. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling.
    Title: The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
  7. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin
    Title: Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin.
  8. We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability.
    Title: Genome-wide association study of diabetic retinopathy in a Taiwanese population.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of conduct disorder symptomatology.
EBI GWAS Catalog
Genome-wide association study of diabetic retinopathy in a Taiwanese population.
EBI GWAS Catalog
The molecular genetic architecture of self-employment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 22
Names
rho-type GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053158.1 RefSeqGene

    Range
    56193..215230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256024.2 → NP_001242953.1  rho GTPase-activating protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001242953.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC016397, AC016399, BC126444, DB338179
    Consensus CDS
    CCDS58080.1
    UniProtKB/TrEMBL
    A0A2X0SFC0, B3KNU1
    Related
    ENSP00000412461.2, ENST00000417912.6
    Conserved Domains (3) summary
    cd04390
    Location:167 → 365
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:36 → 151
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:606 → 694
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001256025.3 → NP_001242954.1  rho GTPase-activating protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001242954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AK293579, AY324801, DC391765
    Consensus CDS
    CCDS58081.1
    UniProtKB/TrEMBL
    B3KNU1
    Related
    ENSP00000416701.2, ENST00000435790.6
    Conserved Domains (4) summary
    cd04390
    Location:157 → 355
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44 → 150
    PH; PH domain
    cl05005
    Location:556 → 685
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  3. NM_001256026.2 → NP_001242955.1  rho GTPase-activating protein 22 isoform 4

    See identical proteins and their annotated locations for NP_001242955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, uses an alternate in-frame splice site in a 5' exon, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016397, AK127586, DB338179
    Consensus CDS
    CCDS58079.1
    UniProtKB/TrEMBL
    B3KNU1
    Related
    ENSP00000410054.2, ENST00000417247.6
    Conserved Domains (4) summary
    cd04390
    Location:61 → 259
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:29 → 54
    PH; PH domain
    cl05005
    Location:460 → 589
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  4. NM_001347735.2 → NP_001334664.1  rho GTPase-activating protein 22 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
    UniProtKB/TrEMBL
    B3KNU1

  5. NM_001347736.2 → NP_001334665.1  rho GTPase-activating protein 22 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC016399, AC068898
    Conserved Domains (1) summary
    cl17171
    Location:42 → 84
    PH-like; Pleckstrin homology-like domain

  6. NM_001347737.2 → NP_001334666.1  rho GTPase-activating protein 22 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016399

  7. NM_001347738.2 → NP_001334667.1  rho GTPase-activating protein 22 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC016397, AC016399, AC068898
    Consensus CDS
    CCDS58081.1
    UniProtKB/TrEMBL
    B3KNU1

  8. NM_021226.4 → NP_067049.2  rho GTPase-activating protein 22 isoform 3

    See identical proteins and their annotated locations for NP_067049.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared with isoform 1.
    Source sequence(s)
    AY324801
    Consensus CDS
    CCDS7227.1
    UniProtKB/Swiss-Prot
    A0AVP7, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0, Q7Z5H3
    UniProtKB/TrEMBL
    B3KNU1
    Related
    ENSP00000249601.4, ENST00000249601.9
    Conserved Domains (4) summary
    cd04390
    Location:151 → 349
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:36 → 151
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:38 → 144
    PH; PH domain
    cl05005
    Location:550 → 679
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RNA

  1. NR_045675.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains alternate 5' exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016397, AK055937, DB338179
    Related
    ENST00000460425.1

  2. NR_144642.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

  3. NR_144643.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

  4. NR_144644.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

  5. NR_144645.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

  6. NR_144646.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    48429831..48656265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448100.2 → XP_024303868.1  rho GTPase-activating protein 22 isoform X14

    Conserved Domains (2) summary
    cd04390
    Location:157 → 347
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain

  2. XM_011540013.4 → XP_011538315.1  rho GTPase-activating protein 22 isoform X12

    Conserved Domains (3) summary
    cd04390
    Location:173 → 363
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44 → 150
    PH; PH domain

  3. XM_017016476.2 → XP_016871965.1  rho GTPase-activating protein 22 isoform X16

  4. XM_011540003.2 → XP_011538305.1  rho GTPase-activating protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011538305.1

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612 → 700
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_011540006.3 → XP_011538308.1  rho GTPase-activating protein 22 isoform X5

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (4) summary
    cd04390
    Location:114 → 312
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:44 → 111
    PH; PH domain
    cl05005
    Location:513 → 642
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:42 → 127
    PH-like; Pleckstrin homology-like domain

  6. XM_047425586.1 → XP_047281542.1  rho GTPase-activating protein 22 isoform X2

  7. XM_011540015.4 → XP_011538317.1  rho GTPase-activating protein 22 isoform X17

    Conserved Domains (3) summary
    cd04390
    Location:173 → 351
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44 → 150
    PH; PH domain

  8. XM_011540002.3 → XP_011538304.1  rho GTPase-activating protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011538304.1

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612 → 700
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_024448099.2 → XP_024303867.1  rho GTPase-activating protein 22 isoform X1

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42 → 157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612 → 700
    SMC_N; RecF/RecN/SMC N terminal domain

  10. XM_011540011.3 → XP_011538313.1  rho GTPase-activating protein 22 isoform X10

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (2) summary
    cd04390
    Location:18 → 216
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl05005
    Location:417 → 546
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  11. XM_047425589.1 → XP_047281545.1  rho GTPase-activating protein 22 isoform X8

    Related
    ENSP00000363285.1, ENST00000374170.5

  12. XM_005270014.4 → XP_005270071.1  rho GTPase-activating protein 22 isoform X6

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (4) summary
    cd04390
    Location:77 → 275
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:29 → 54
    PH; PH domain
    cl05005
    Location:476 → 605
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  13. XM_011540005.2 → XP_011538307.1  rho GTPase-activating protein 22 isoform X4

    UniProtKB/TrEMBL
    B3KNU1
    Related
    ENSP00000363287.1, ENST00000374172.5
    Conserved Domains (4) summary
    cd04390
    Location:77 → 275
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:29 → 54
    PH; PH domain
    cl05005
    Location:476 → 605
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  14. XM_047425588.1 → XP_047281544.1  rho GTPase-activating protein 22 isoform X7

  15. XM_047425590.1 → XP_047281546.1  rho GTPase-activating protein 22 isoform X9

  16. XM_047425591.1 → XP_047281547.1  rho GTPase-activating protein 22 isoform X9

  17. XM_047425587.1 → XP_047281543.1  rho GTPase-activating protein 22 isoform X3

  18. XM_017016471.3 → XP_016871960.1  rho GTPase-activating protein 22 isoform X11

    UniProtKB/TrEMBL
    B3KNU1
    Conserved Domains (2) summary
    cd04390
    Location:5 → 203
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl05005
    Location:404 → 533
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  19. XM_047425593.1 → XP_047281549.1  rho GTPase-activating protein 22 isoform X15

  20. XM_047425592.1 → XP_047281548.1  rho GTPase-activating protein 22 isoform X13

  21. XM_047425594.1 → XP_047281550.1  rho GTPase-activating protein 22 isoform X18

  22. XM_047425595.1 → XP_047281551.1  rho GTPase-activating protein 22 isoform X20

  23. XM_024448102.2 → XP_024303870.1  rho GTPase-activating protein 22 isoform X19

    Conserved Domains (1) summary
    cl17171
    Location:42 → 130
    PH-like; Pleckstrin homology-like domain

  24. XM_024448106.2 → XP_024303874.1  rho GTPase-activating protein 22 isoform X21

    Conserved Domains (1) summary
    cl17171
    Location:42 → 84
    PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    49275552..49505563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366471.1 → XP_054222446.1  rho GTPase-activating protein 22 isoform X14

  2. XM_054366469.1 → XP_054222444.1  rho GTPase-activating protein 22 isoform X12

  3. XM_054366473.1 → XP_054222448.1  rho GTPase-activating protein 22 isoform X16

  4. XM_054366457.1 → XP_054222432.1  rho GTPase-activating protein 22 isoform X1

  5. XM_054366458.1 → XP_054222433.1  rho GTPase-activating protein 22 isoform X2

  6. XM_054366455.1 → XP_054222430.1  rho GTPase-activating protein 22 isoform X1

  7. XM_054366461.1 → XP_054222436.1  rho GTPase-activating protein 22 isoform X5

  8. XM_054366474.1 → XP_054222449.1  rho GTPase-activating protein 22 isoform X17

  9. XM_054366456.1 → XP_054222431.1  rho GTPase-activating protein 22 isoform X1

  10. XM_054366464.1 → XP_054222439.1  rho GTPase-activating protein 22 isoform X8

  11. XM_054366462.1 → XP_054222437.1  rho GTPase-activating protein 22 isoform X6

  12. XM_054366460.1 → XP_054222435.1  rho GTPase-activating protein 22 isoform X4

  13. XM_054366463.1 → XP_054222438.1  rho GTPase-activating protein 22 isoform X7

  14. XM_054366465.1 → XP_054222440.1  rho GTPase-activating protein 22 isoform X9

  15. XM_054366468.1 → XP_054222443.1  rho GTPase-activating protein 22 isoform X22

  16. XM_054366466.1 → XP_054222441.1  rho GTPase-activating protein 22 isoform X9

  17. XM_054366459.1 → XP_054222434.1  rho GTPase-activating protein 22 isoform X3

  18. XM_054366467.1 → XP_054222442.1  rho GTPase-activating protein 22 isoform X11

  19. XM_054366472.1 → XP_054222447.1  rho GTPase-activating protein 22 isoform X15

  20. XM_054366470.1 → XP_054222445.1  rho GTPase-activating protein 22 isoform X13

  21. XM_054366475.1 → XP_054222450.1  rho GTPase-activating protein 22 isoform X18

  22. XM_054366477.1 → XP_054222452.1  rho GTPase-activating protein 22 isoform X23

  23. XM_054366479.1 → XP_054222454.1  rho GTPase-activating protein 22 isoform X20

  24. XM_054366476.1 → XP_054222451.1  rho GTPase-activating protein 22 isoform X23

  25. XM_054366478.1 → XP_054222453.1  rho GTPase-activating protein 22 isoform X19

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256027.1: Suppressed sequence

    Description
    NM_001256027.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z5H3.1 GenPept UniProtKB/Swiss-Prot:Q7Z5H3

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