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Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 [ Mus musculus (house mouse) ]

Gene ID: 58801, updated on 11-Jan-2022

Summary

Official Symbol
Pmaip1provided by MGI
Official Full Name
phorbol-12-myristate-13-acetate-induced protein 1provided by MGI
Primary source
MGI:MGI:1930146
See related
Ensembl:ENSMUSG00000024521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Noxa
Summary
Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and response to X-ray. Located in mitochondrion. Is expressed in several structures, including brain; immune system; limb; liver; and reproductive system. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in placenta adult (RPKM 5.1), large intestine adult (RPKM 3.2) and 22 other tissues See more
Orthologs
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Genomic context

See Pmaip1 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66591675..66598629)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66458604..66465558)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (66618258..66625212)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene collagen and calcium binding EGF domains 1 Neighboring gene microRNA 694 Neighboring gene predicted gene, 20294 Neighboring gene predicted gene 9926 Neighboring gene predicted gene, 24679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to dsRNA ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phorbol-12-myristate-13-acetate-induced protein 1
Names
protein Noxa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021451.2NP_067426.1  phorbol-12-myristate-13-acetate-induced protein 1

    See identical proteins and their annotated locations for NP_067426.1

    Status: PROVISIONAL

    Source sequence(s)
    AC100212
    Consensus CDS
    CCDS29315.1
    UniProtKB/Swiss-Prot
    Q9JM54
    Related
    ENSMUSP00000025399.8, ENSMUST00000025399.9
    Conserved Domains (1) summary
    pfam15150
    Location:50103
    PMAIP1; Phorbol-12-myristate-13-acetate-induced

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66591675..66598629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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