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Rnase4 ribonuclease, RNase A family 4 [ Mus musculus (house mouse) ]

Gene ID: 58809, updated on 5-Mar-2024

Summary

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Official Symbol
Rnase4provided by MGI
Official Full Name
ribonuclease, RNase A family 4provided by MGI
Primary source
MGI:MGI:1926217
See related
Ensembl:ENSMUSG00000021876 AllianceGenome:MGI:1926217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab1; C730049F20Rik
Summary
This gene encodes a member of the pancreatic ribonuclease A superfamily. The encoded enzyme is sereted and has unique uridine specificity. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the angiogenin, ribonuclease, RNase A family, 5 gene. Each gene splices to a unique downstream exon that contains its complete coding region. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. [provided by RefSeq, Jun 2009]
Expression
Biased expression in liver adult (RPKM 541.8), lung adult (RPKM 184.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C1; 14 26.37 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51328534..51343608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51091077..51106151)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5432 Neighboring gene STARR-positive B cell enhancer ABC_E3111 Neighboring gene nuclear encoded tRNA tyrosine 10 (anticodon GTA) Neighboring gene nuclear encoded tRNA proline 5 (anticodon TGG) Neighboring gene angiogenin, ribonuclease, RNase A family, 5 Neighboring gene STARR-positive B cell enhancer ABC_E4108 Neighboring gene epididymal protein 3B Neighboring gene ribonuclease, RNase A family, 6 Neighboring gene STARR-positive B cell enhancer ABC_E9895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribonuclease 4, an evolutionarily highly conserved member of the superfamily. Hofsteenge J, et al. Cell Mol Life Sci, 1998 Aug. PMID 9760989
  2. The RNase a superfamily: generation of diversity and innate host defense. Dyer KD, et al. Mol Divers, 2006 Nov. PMID 16969722
  3. The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression. Dyer KD, et al. Nucleic Acids Res, 2005. PMID 15722482, Free PMC Article
  4. Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. Hsieh YC, et al. Shock, 2004 Jun. PMID 15167684
  5. Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses. Murtha MJ, et al. J Clin Invest, 2018 Dec 3. PMID 30418175, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease 4
Names
RNase 4
ribonuclease A b1
NP_067447.2
NP_957691.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021472.4 → NP_067447.2  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_067447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163664, BC061105, CD742377
    Consensus CDS
    CCDS27035.1
    UniProtKB/Swiss-Prot
    Q9JJH1
    UniProtKB/TrEMBL
    Q5UCA9, Q8C7E4
    Related
    ENSMUSP00000022428.6, ENSMUST00000022428.13
    Conserved Domains (1) summary
    smart00092
    Location:30 → 148
    RNAse_Pc; Pancreatic ribonuclease

  2. NM_201239.3 → NP_957691.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_957691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163664, AK050451, CD742377
    Consensus CDS
    CCDS27035.1
    UniProtKB/Swiss-Prot
    Q9JJH1
    UniProtKB/TrEMBL
    Q5UCA9, Q8C7E4
    Related
    ENSMUSP00000127274.2, ENSMUST00000169895.3
    Conserved Domains (1) summary
    smart00092
    Location:30 → 148
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51328534..51343608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJH1.1 GenPept UniProtKB/Swiss-Prot:Q9JJH1

Gene LinkOut

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