Prg2 proteoglycan 2, pro eosinophil major basic protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prg2provided by RGD
Official Full Name: proteoglycan 2, pro eosinophil major basic proteinprovided by RGD
Primary source: RGD:69336
See related: Ensembl:ENSRNOG00000008394 AllianceGenome:RGD:69336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within defense response to nematode; negative regulation of interleukin-10 production; and positive regulation of interleukin-4 production. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 655.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90469192..90472759)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (70062535..70066102)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72385678..72389245)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pretreatment with major basic protein did not significantly alter input resistance of vagal sensory neurons. sensitizing effect of MBP was completely abolished when its cationic charge was neutralized by mixing with a polyanion.
Title: Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to nematode	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to nematode	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone marrow proteoglycan

Names: BMPG; eosinophil major basic protein; proteoglycan 2, bone marrow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031619.2 → NP_113807.2 bone marrow proteoglycan precursor

See identical proteins and their annotated locations for NP_113807.2

Status: VALIDATED

Source sequence(s)

CA509460, CB703061, D50568

UniProtKB/Swiss-Prot

Q63189

UniProtKB/TrEMBL

A6HMS5, G3V729

Related

ENSRNOP00000011168.1, ENSRNOT00000011168.4

Conserved Domains (1) summary

cd03598
Location:113 → 227

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)