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Hgfac HGF activator [ Rattus norvegicus (Norway rat) ]

Gene ID: 58947, updated on 5-Mar-2024

Summary

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Official Symbol
Hgfacprovided by RGD
Official Full Name
HGF activatorprovided by RGD
Primary source
RGD:70909
See related
Ensembl:ENSRNOG00000009572 AllianceGenome:RGD:70909
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and rough endoplasmic reticulum. Orthologous to human HGFAC (HGF activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 776.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79932219..79938773, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75707588..75714182, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80966902..80973525, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein associated protein 1 Neighboring gene docking protein 7 Neighboring gene regulator of G-protein signaling 12 Neighboring gene ribosomal protein S17 like 4 Neighboring gene regulator of G-protein signaling 12 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Kaibori M, et al. Biochem Biophys Res Commun, 2002 Jan 11. PMID 11779195
  2. Changes in gene expression during progression of ovarian carcinoma. Tapper J, et al. Cancer Genet Cytogenet, 2001 Jul 1. PMID 11454421
  3. Immunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues. Heterogeneous distribution of HGFA protein. Iida I, et al. J Histochem Cytochem, 2003 Sep. PMID 12923239
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109000

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hepatocyte growth factor activator
NP_445772.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053320.1 → NP_445772.1  hepatocyte growth factor activator precursor

    See identical proteins and their annotated locations for NP_445772.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089871
    UniProtKB/TrEMBL
    F7ELL4, Q5EBA7
    Related
    ENSRNOP00000013257.5, ENSRNOT00000013257.7
    Conserved Domains (7) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    smart00020
    Location:405 → 639
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:197 → 237
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:406 → 641
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:242 → 274
    EGF; EGF-like domain
    pfam00051
    Location:283 → 364
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    79932219..79938773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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