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F12 coagulation factor XII (Hageman factor) [ Mus musculus (house mouse) ]

Gene ID: 58992, updated on 16-Oct-2021

Summary

Official Symbol
F12provided by MGI
Official Full Name
coagulation factor XII (Hageman factor)provided by MGI
Primary source
MGI:MGI:1891012
See related
Ensembl:ENSMUSG00000021492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAF; FXII
Summary
This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]
Expression
Biased expression in liver adult (RPKM 284.9), liver E18 (RPKM 133.3) and 2 other tissues See more
Orthologs
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Genomic context

See F12 in Genome Data Viewer
Location:
13; 13 B1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55565771..55574617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55417958..55426804, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55519327..55528163, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 14 Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Factor XII activation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma kallikrein-kinin cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
coagulation factor XII
Names
factor XII
hageman factor
NP_067464.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021489.3NP_067464.2  coagulation factor XII preproprotein

    See identical proteins and their annotated locations for NP_067464.2

    Status: REVIEWED

    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS36675.1
    UniProtKB/Swiss-Prot
    Q80YC5
    Related
    ENSMUSP00000021948.9, ENSMUST00000021948.15
    Conserved Domains (7) summary
    smart00020
    Location:354591
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:96131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133173
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:4188
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00190
    Location:355594
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:178206
    EGF; EGF-like domain
    cl00100
    Location:217295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55565771..55574617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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