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Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 [ Mus musculus (house mouse) ]

Gene ID: 59013, updated on 21-Apr-2024

Summary

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Official Symbol
Hnrnph1provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein H1provided by MGI
Primary source
MGI:MGI:1891925
See related
Ensembl:ENSMUSG00000007850 AllianceGenome:MGI:1891925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrnph; Hnrph1; E430005G16Rik
Summary
Predicted to enable RNA binding activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within cellular response to interleukin-7. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm. Is expressed in brain; gut; liver; metanephros; and respiratory system. Human ortholog(s) of this gene implicated in Sjogren's syndrome. Orthologous to human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 294.5), CNS E14 (RPKM 202.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 30.56 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50266084..50277355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50375257..50386528)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene predicted gene, 53701 Neighboring gene STARR-positive B cell enhancer ABC_E6978 Neighboring gene microRNA 804 Neighboring gene chibby family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50190892-50191075 Neighboring gene STARR-positive B cell enhancer ABC_E2985 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2986 Neighboring gene STARR-positive B cell enhancer ABC_E5222 Neighboring gene predicted gene, 53702

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice. Borrelli KN, et al. Psychopharmacology (Berl), 2021 Jul. PMID 33758972, Free PMC Article
  2. Hnrnph1 is a novel regulator of alcohol reward. Fultz EK, et al. Drug Alcohol Depend, 2021 Mar 1. PMID 33454624, Free PMC Article
  3. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice. Bryant CD, et al. Genes Brain Behav, 2021 Mar. PMID 33145940
  4. Heterogeneous nuclear ribonucleoprotein-H plays a suppressive role in visceral myogenesis. Liu J, et al. Mech Dev, 2001 Jun. PMID 11404082
  5. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. Ruan QT, et al. FASEB J, 2020 Jul. PMID 32401417, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
    Title: A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
  2. hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
    Title: hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
  3. hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
    Title: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
  4. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
    Title: Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
  5. The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis.
    Title: The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis.
  6. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.
    Title: Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.
  7. Hnrnph1 is a novel regulator of alcohol reward.
    Title: Hnrnph1 is a novel regulator of alcohol reward.
  8. There is a role for the RNA binding protein hnRNP H in methamphetamine reward and reinforcement. Hnrnph1 mutation also blunted methamphetamine-induced dopamine release in the NAc, a key neurochemical event contributing to methamphetamine addiction liability. Finally, Hnrnph1 mutants showed a marked increase in basal level of synaptosomal hnRNP H and mitochondrial proteins that decreased in response to methamphetamine.
    Title: A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.
  9. These results define a novel contribution of Hnrnph1 to neurobehavioral dysfunction associated with dopaminergic neurotransmission.
    Title: Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity.
  10. hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
    Title: Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to interleukin-7 IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347487.2 → NP_001334416.1  heterogeneous nuclear ribonucleoprotein H isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA124353, AK165283, AL645904, BY307937, BY787002, CO426010, DV657681
    Consensus CDS
    CCDS83800.1
    UniProtKB/TrEMBL
    Q8C2Q7
    Related
    ENSMUSP00000076989.8, ENSMUST00000077817.8
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  2. NM_001362522.1 → NP_001349451.1  heterogeneous nuclear ribonucleoprotein H isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  3. NM_001362523.1 → NP_001349452.1  heterogeneous nuclear ribonucleoprotein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK161491, AL645904
    Consensus CDS
    CCDS24634.1
    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Related
    ENSMUSP00000104770.2, ENSMUST00000109142.8
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  4. NM_001362524.1 → NP_001349453.1  heterogeneous nuclear ribonucleoprotein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Consensus CDS
    CCDS24634.1
    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  5. NM_001362525.1 → NP_001349454.1  heterogeneous nuclear ribonucleoprotein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Consensus CDS
    CCDS24634.1
    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  6. NM_001362526.1 → NP_001349455.1  heterogeneous nuclear ribonucleoprotein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Consensus CDS
    CCDS24634.1
    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  7. NM_001362527.1 → NP_001349456.1  heterogeneous nuclear ribonucleoprotein H isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  8. NM_001362528.1 → NP_001349457.1  heterogeneous nuclear ribonucleoprotein H isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  9. NM_001362529.1 → NP_001349458.1  heterogeneous nuclear ribonucleoprotein H isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  10. NM_001362530.1 → NP_001349459.1  heterogeneous nuclear ribonucleoprotein H isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  11. NM_001362532.1 → NP_001349461.1  heterogeneous nuclear ribonucleoprotein H isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  12. NM_001362533.1 → NP_001349462.1  heterogeneous nuclear ribonucleoprotein H isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL645904
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  13. NM_001362534.1 → NP_001349463.1  heterogeneous nuclear ribonucleoprotein H isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL645904
    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  14. NM_021510.3 → NP_067485.1  heterogeneous nuclear ribonucleoprotein H isoform 2

    See identical proteins and their annotated locations for NP_067485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL645904, BE952242, BQ178089, BU058854, BY787002, CO428102
    Consensus CDS
    CCDS24634.1
    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Related
    ENSMUSP00000070503.8, ENSMUST00000069304.14
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50266084..50277355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246205.2 → XP_030102065.1  heterogeneous nuclear ribonucleoprotein H isoform X7

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  2. XM_036156886.1 → XP_036012779.1  heterogeneous nuclear ribonucleoprotein H isoform X13

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  3. XM_036156883.1 → XP_036012776.1  heterogeneous nuclear ribonucleoprotein H isoform X11

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  4. XM_036156884.1 → XP_036012777.1  heterogeneous nuclear ribonucleoprotein H isoform X13

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  5. XM_036156878.1 → XP_036012771.1  heterogeneous nuclear ribonucleoprotein H isoform X4

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  6. XM_036156875.1 → XP_036012768.1  heterogeneous nuclear ribonucleoprotein H isoform X1

    UniProtKB/TrEMBL
    Q8C2Q7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  7. XM_006533879.3 → XP_006533942.1  heterogeneous nuclear ribonucleoprotein H isoform X3

    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_017314694.2 → XP_017170183.1  heterogeneous nuclear ribonucleoprotein H isoform X10

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  9. XM_030246204.2 → XP_030102064.1  heterogeneous nuclear ribonucleoprotein H isoform X6

    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_036156880.1 → XP_036012773.1  heterogeneous nuclear ribonucleoprotein H isoform X7

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  11. XM_036156877.1 → XP_036012770.1  heterogeneous nuclear ribonucleoprotein H isoform X2

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  12. XM_036156885.1 → XP_036012778.1  heterogeneous nuclear ribonucleoprotein H isoform X13

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  13. XM_036156882.1 → XP_036012775.1  heterogeneous nuclear ribonucleoprotein H isoform X11

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  14. XM_036156881.1 → XP_036012774.1  heterogeneous nuclear ribonucleoprotein H isoform X9

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  15. XM_006533881.4 → XP_006533944.1  heterogeneous nuclear ribonucleoprotein H isoform X8

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  16. XM_036156876.1 → XP_036012769.1  heterogeneous nuclear ribonucleoprotein H isoform X1

    UniProtKB/TrEMBL
    Q8C2Q7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  17. XM_036156879.1 → XP_036012772.1  heterogeneous nuclear ribonucleoprotein H isoform X5

    UniProtKB/Swiss-Prot
    O35737
    UniProtKB/TrEMBL
    Q811L7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  18. XM_030246212.2 → XP_030102072.1  heterogeneous nuclear ribonucleoprotein H isoform X13

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  19. XM_030246209.2 → XP_030102069.1  heterogeneous nuclear ribonucleoprotein H isoform X11

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  20. XM_030246207.1 → XP_030102067.1  heterogeneous nuclear ribonucleoprotein H isoform X9

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  21. XM_030246206.1 → XP_030102066.1  heterogeneous nuclear ribonucleoprotein H isoform X8

    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  22. XM_006533877.4 → XP_006533940.1  heterogeneous nuclear ribonucleoprotein H isoform X1

    See identical proteins and their annotated locations for XP_006533940.1

    UniProtKB/TrEMBL
    Q8C2Q7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  23. XM_030246210.2 → XP_030102070.1  heterogeneous nuclear ribonucleoprotein H isoform X12

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    cd12734
    Location:81 → 156
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:54 → 82
    zf-RNPHF; RNPHF zinc finger

  24. XM_017314697.3 → XP_017170186.1  heterogeneous nuclear ribonucleoprotein H isoform X14

    UniProtKB/TrEMBL
    Q3TNG9
    Conserved Domains (2) summary
    cd12734
    Location:81 → 156
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:54 → 82
    zf-RNPHF; RNPHF zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35737.3 GenPept UniProtKB/Swiss-Prot:O35737

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