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Slc4a8 solute carrier family 4 (anion exchanger), member 8 [ Mus musculus (house mouse) ]

Gene ID: 59033, updated on 23-Jun-2021

Summary

Official Symbol
Slc4a8provided by MGI
Official Full Name
solute carrier family 4 (anion exchanger), member 8provided by MGI
Primary source
MGI:MGI:1928745
See related
Ensembl:ENSMUSG00000023032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NDCB; KNBC-; NDCBE; kNBC-3; AW493845; C230026C11
Expression
Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 7.4) and 19 other tissues See more
Orthologs
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Genomic context

See Slc4a8 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100659628..100721852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100761747..100823971)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100592178..100654402)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene predicted gene, 52175 Neighboring gene predicted gene, 41401 Neighboring gene predicted gene, 35569 Neighboring gene sodium channel, voltage-gated, type VIII, alpha Neighboring gene predicted gene, 52176

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables anion:anion antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables inorganic anion exchanger activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in hippocampal mossy fiber ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in symmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
electroneutral sodium bicarbonate exchanger 1
Names
electroneutral Na+-driven Cl-HCO3 exchanger
k-NBC3
solute carrier family 4 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347102.1NP_001334031.1  electroneutral sodium bicarbonate exchanger 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113587, AK141910, AK171610, BP759706
    Consensus CDS
    CCDS84193.1
    UniProtKB/Swiss-Prot
    Q8JZR6
    UniProtKB/TrEMBL
    Q3UR07
    Related
    ENSMUSP00000125090.2, ENSMUST00000162049.2
    Conserved Domains (1) summary
    cl26877
    Location:65951
    Band_3_cyto; Band 3 cytoplasmic domain
  2. NM_021530.2NP_067505.2  electroneutral sodium bicarbonate exchanger 1 isoform 1

    See identical proteins and their annotated locations for NP_067505.2

    Status: VALIDATED

    Source sequence(s)
    AC113587, AK173014, BB626223, BB851903, BP759706
    Consensus CDS
    CCDS37214.1
    UniProtKB/Swiss-Prot
    Q8JZR6
    Related
    ENSMUSP00000023776.7, ENSMUST00000023776.13
    Conserved Domains (3) summary
    TIGR00834
    Location:1171003
    ae; anion exchange protein
    pfam00955
    Location:443956
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:145402
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100659628..100721852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316718.2XP_017172207.1  electroneutral sodium bicarbonate exchanger 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8JZR6
    Conserved Domains (1) summary
    cl26877
    Location:65951
    Band_3_cyto; Band 3 cytoplasmic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033218.1: Suppressed sequence

    Description
    NM_001033218.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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