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Grk6 G protein-coupled receptor kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59076, updated on 23-Jul-2021

Summary

Official Symbol
Grk6provided by RGD
Official Full Name
G protein-coupled receptor kinase 6provided by RGD
Primary source
RGD:61986
See related
Ensembl:ENSRNOG00000014615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gprk6
Summary
G-protein coupled receptor kinase that desensitizes beta adrenergic receptors in myometrium [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 344.0), Spleen (RPKM 326.2) and 9 other tissues See more
Orthologs
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Genomic context

See Grk6 in Genome Data Viewer
Location:
17p14
Exon count:
17
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9177018..9192644, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9705917..9721921, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 Neighboring gene drebrin 1 Neighboring gene proline rich 7 (synaptic) Neighboring gene coagulation factor XII Neighboring gene profilin 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-adrenergic receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-adrenergic receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G protein-coupled receptor kinase 6
Names
g protein-coupled receptor kinase GRK6
NP_001106183.1
NP_001106184.1
NP_113845.2
XP_008769726.1
XP_038951961.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112712.2NP_001106183.1  G protein-coupled receptor kinase 6 isoform c

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000284
    UniProtKB/TrEMBL
    P97548
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001112713.1NP_001106184.1  G protein-coupled receptor kinase 6 isoform b

    Status: VALIDATED

    Source sequence(s)
    AF040750, EX488847
    UniProtKB/TrEMBL
    F1LNP2, Q792R1
    Related
    ENSRNOP00000050134.4, ENSRNOT00000047958.4
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_031657.4NP_113845.2  G protein-coupled receptor kinase 6 isoform a

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000284
    UniProtKB/TrEMBL
    A0A0G2K6E5, P97549
    Related
    ENSRNOP00000073781.1, ENSRNOT00000079063.1
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    9177018..9192644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771504.2XP_008769726.1  G protein-coupled receptor kinase 6 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:32294
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:31315
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:125
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_039096033.1XP_038951961.1  G protein-coupled receptor kinase 6 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
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