Fxyd6 FXYD domain-containing ion transport regulator 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fxyd6provided by MGI
Official Full Name: FXYD domain-containing ion transport regulator 6provided by MGI
Primary source: MGI:MGI:1890226
See related: Ensembl:ENSMUSG00000066705 AllianceGenome:MGI:1890226
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Php; 0610030I18Rik
Summary: This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]
Expression: Broad expression in CNS E18 (RPKM 180.7), whole brain E14.5 (RPKM 104.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45280768..45307457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45369470..45396159)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells. Fxyd6 is coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the taste signal transduction pathways.
Title: FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells.
FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear.
Title: FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ion channel regulator activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: FXYD domain-containing ion transport regulator 6

Names: PLM-like protein; phosphohippolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022004.6 → NP_071287.1 FXYD domain-containing ion transport regulator 6 precursor

See identical proteins and their annotated locations for NP_071287.1

Status: REVIEWED

Source sequence(s)

AK003888, BG093642, BQ891313, BY081454

Consensus CDS

CCDS23133.1

UniProtKB/Swiss-Prot

Q99NC3, Q9CXD0, Q9D164

Related

ENSMUSP00000083101.7, ENSMUST00000085939.8

Conserved Domains (1) summary

cl40453
Location:2 → 93

FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

45280768..45307457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244486.1 → XP_030100346.1 FXYD domain-containing ion transport regulator 6 isoform X1

Conserved Domains (1) summary

pfam02038
Location:178 → 223

ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
XM_036155163.1 → XP_036011056.1 FXYD domain-containing ion transport regulator 6 isoform X2

UniProtKB/Swiss-Prot

Q99NC3, Q9CXD0, Q9D164

Conserved Domains (1) summary

cl40453
Location:2 → 93

FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
XM_036155164.1 → XP_036011057.1 FXYD domain-containing ion transport regulator 6 isoform X2

UniProtKB/Swiss-Prot

Q99NC3, Q9CXD0, Q9D164

Conserved Domains (1) summary

cl40453
Location:2 → 93

FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family