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Fxyd6 FXYD domain-containing ion transport regulator 6 [ Mus musculus (house mouse) ]

Gene ID: 59095, updated on 8-Jul-2021

Summary

Official Symbol
Fxyd6provided by MGI
Official Full Name
FXYD domain-containing ion transport regulator 6provided by MGI
Primary source
MGI:MGI:1890226
See related
Ensembl:ENSMUSG00000066705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; Php; 0610030I18Rik
Summary
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006]
Expression
Broad expression in CNS E18 (RPKM 180.7), whole brain E14.5 (RPKM 104.7) and 19 other tissues See more
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Genomic context

See Fxyd6 in Genome Data Viewer
Location:
9; 9 A5.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45280768..45307457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45369470..45396159)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45178268..45204242)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13 Neighboring gene uncharacterized LOC118567699 Neighboring gene RIKEN cDNA 4833428L15 gene Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene DS cell adhesion molecule like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FXYD domain-containing ion transport regulator 6
Names
PLM-like protein
phosphohippolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022004.6NP_071287.1  FXYD domain-containing ion transport regulator 6 precursor

    See identical proteins and their annotated locations for NP_071287.1

    Status: REVIEWED

    Source sequence(s)
    AK003888, BG093642, BQ891313, BY081454
    Consensus CDS
    CCDS23133.1
    UniProtKB/Swiss-Prot
    Q9D164
    Related
    ENSMUSP00000083101.7, ENSMUST00000085939.8
    Conserved Domains (1) summary
    cl40453
    Location:293
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45280768..45307457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244486.1XP_030100346.1  FXYD domain-containing ion transport regulator 6 isoform X1

    Conserved Domains (1) summary
    pfam02038
    Location:178223
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
  2. XM_036155163.1XP_036011056.1  FXYD domain-containing ion transport regulator 6 isoform X2

    Conserved Domains (1) summary
    cl40453
    Location:293
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
  3. XM_036155164.1XP_036011057.1  FXYD domain-containing ion transport regulator 6 isoform X2

    Conserved Domains (1) summary
    cl40453
    Location:293
    FXYD; phenylalanine-X-tyrosine-aspartate (FXYD) family
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