Mb myoglobin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mbprovided by RGD
Official Full Name: myoglobinprovided by RGD
Primary source: RGD:620411
See related: Ensembl:ENSRNOG00000004583 AllianceGenome:RGD:620411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glng
Summary: Enables oxygen binding activity. Involved in several processes, including oxygen transport; response to hydrogen peroxide; and slow-twitch skeletal muscle fiber contraction. Used to study acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 63389.2) and Muscle (RPKM 25407.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (110640511..110647742, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108759903..108767134, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (118101633..118108864, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myoglobin and troponin concentrations are increased in early stage deep tissue injury
Title: Myoglobin and troponin concentrations are increased in early stage deep tissue injury.
In rhabdomyolytic rats, the level of heme and free iron in cytoplasm and mitochondria of kidney cells is remarkably increased while inhibition of proteolysis results in further elevation of myoglobin content in the renal tissue.
Title: The role of myoglobin degradation in nephrotoxicity after rhabdomyolysis.
After reperfusion, there was no significant increase in dialysate myoglobin concentration. MDL-28170 did not affect dialysate myoglobin concentration during occlusion or after reperfusion.
Title: Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats.
Amphetamine-induced serum myoglobin release is a potential biomarker and possibly a factor in AMPH-induced toxicity processes.
Title: Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity.
Data suggest that rhabdomyolysis-induced kidney damage involves direct interaction of myoglobin with mitochondria possibly resulting in iron ions release from myoglobin's heme, which promotes the peroxidation of mitochondrial membranes.
Title: Myoglobin causes oxidative stress, increase of NO production and dysfunction of kidney's mitochondria.
intermittent hypobaric hypoxia decreased myocardial citrate synthase activity and myoglobin and decreased myocardial lactate dehydrogenase activity
Title: Enzyme activity and myoglobin concentration in rat myocardium and skeletal muscles after passive intermittent simulated altitude exposure.
The nitrite reductase activity of deoxymyoglobin reduces nitrite approximately 36 times faster than deoxyhemoglobin because of its lower heme redox potential.
Title: Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.
Moreover, the similar Q10 for the DMb of solution versus cell Mb suggests that any temperature-dependent alteration of the postulated cell matrix does not significantly affect protein mobility.
Title: Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture.
Mb-facilitated diffusion has a higher poise in skeletal muscle than in myocardium.
Title: Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport.
bradykinin-induced NO does not interact significantly with cellular Mb to produce an NMR-detectable quantity of metMb in the perfused rat myocardium
Title: Role of myoglobin as a scavenger of cellular NO in myocardium.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MB (e-PCR)
- UniSTS:253987

Mb (e-PCR), detects polymorphism
- UniSTS:499125

RH134536 (e-PCR)
- UniSTS:217816

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	NAS Non-traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISO Inferred from Sequence Orthology more info
enables oxygen carrier activity	ISS Inferred from Sequence or Structural Similarity more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enucleate erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxygen transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in slow-twitch skeletal muscle fiber contraction	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myoglobin

Names: globin g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.