RARA retinoic acid receptor alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: RARAprovided by HGNC
Official Full Name: retinoic acid receptor alphaprovided by HGNC
Primary source: HGNC:HGNC:9864
See related: Ensembl:ENSG00000131759 MIM:180240; AllianceGenome:HGNC:9864
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAR; NR1B1; RARalpha
Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in lung (RPKM 10.4), spleen (RPKM 8.4) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q21.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (40309180..40357643)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (41172682..41221155)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (38465432..38513895)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical Relevance of Differential RARalpha and PPARbeta/delta Expression in Myelodysplastic Syndromes.
Title: Clinical Relevance of Differential RARα and PPARβ/δ Expression in Myelodysplastic Syndromes.
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARalpha.
Title: Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα.
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.
Title: Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.
PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARalpha.
Title: PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.
Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.
Title: Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Title: Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
A novel fusion protein TBLR1-RARalpha acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies.
Title: A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies.
A PML/RARalpha direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.
Title: A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.
Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARalpha transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients.
Title: Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARα transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients.
Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
Title: Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).

Submit: New GeneRIF Correction See all GeneRIFs (229)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acute promyelocytic leukemia MedGen: C0023487 OMIM: 612376 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription	PubMed
matrix	gag	HIV-1 MA upregulates RARA gene expression in HepG2 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

GDB:180970 (e-PCR)
- UniSTS:155148

RH80640 (e-PCR)
- UniSTS:83784

SHGC-83476 (e-PCR)
- UniSTS:183120

Rara (e-PCR), detects polymorphism
- UniSTS:462692

Rara (e-PCR), detects polymorphism
- UniSTS:462695

GDB:376702 (e-PCR)
- UniSTS:157060

SHGC-81199 (e-PCR)
- UniSTS:102022

RARA_480 (e-PCR)
- UniSTS:277659

GDB:625834 (e-PCR)
- UniSTS:158371

G10521 (e-PCR)
- UniSTS:53696

D17S1335 (e-PCR)
- UniSTS:150220

STS-N54985 (e-PCR)
- UniSTS:16876

L17737 (e-PCR)
- UniSTS:72431

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-actinin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables heterocyclic compound binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase B binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinoic acid-responsive element binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Sertoli cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryonic camera-type eye development	IEA Inferred from Electronic Annotation more info
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in glandular epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage development	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in limb development	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cartilage development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea cartilage development	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: retinoic acid receptor alpha

Names: PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR-alpha; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid receptor, alpha polypeptide

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027701.1 RefSeqGene

Range

5010..53473

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1070

mRNA and Protein(s)

NM_000964.4 → NP_000955.1 retinoic acid receptor alpha isoform 1

See identical proteins and their annotated locations for NP_000955.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

BC008727, BM992549, DA061829, X06614

Consensus CDS

CCDS11366.1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

A8K840, Q6I9R7

Related

ENSP00000254066.5, ENST00000254066.10

Conserved Domains (2) summary

cd06937
Location:186 → 416

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:82 → 166

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
NM_001024809.4 → NP_001019980.1 retinoic acid receptor alpha isoform 2

See identical proteins and their annotated locations for NP_001019980.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) reflects the use of an alternate promoter and has a distinct 5' exon, compared to transcript variant 1. Translation is predicted to initiate from this alternate exon, and the resulting protein (isoform 2) has a shorter and a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC080112, BC071733, BM838347, BM992549

Consensus CDS

CCDS42317.1

UniProtKB/TrEMBL

A8K840, F1D8N9

Related

ENSP00000377643.3, ENST00000394081.7

Conserved Domains (2) summary

cd06937
Location:181 → 411

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:77 → 161

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
NM_001145301.3 → NP_001138773.1 retinoic acid receptor alpha isoform 1

See identical proteins and their annotated locations for NP_001138773.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) reflects the use of an alternate promoter and contains a different 5' UTR segment, compared to variant 1. Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK292205, BG394590, BM992549, X06614

Consensus CDS

CCDS11366.1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

A8K840, Q6I9R7

Related

ENSP00000377649.2, ENST00000394089.6

Conserved Domains (2) summary

cd06937
Location:186 → 416

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:82 → 166

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
NM_001145302.3 → NP_001138774.1 retinoic acid receptor alpha isoform 4

See identical proteins and their annotated locations for NP_001138774.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) reflects the use of an alternate promoter and contains a different 5' UTR segment. This variant also lacks two in-frame coding exons, compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.

Source sequence(s)

AC080112, BG394590, BM992549, FJ487576

Consensus CDS

CCDS45671.1

UniProtKB/Swiss-Prot

P10276

Related

ENSP00000389993.3, ENST00000425707.7

Conserved Domains (1) summary

cd06937
Location:89 → 319

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

40309180..40357643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525095.2 → XP_011523397.1 retinoic acid receptor alpha isoform X1

See identical proteins and their annotated locations for XP_011523397.1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

A8K840, Q6I9R7

Conserved Domains (2) summary

cd06937
Location:186 → 416

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:82 → 166

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
XM_047436507.1 → XP_047292463.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_005257554.2 → XP_005257611.1 retinoic acid receptor alpha isoform X1

See identical proteins and their annotated locations for XP_005257611.1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

A8K840, Q6I9R7

Conserved Domains (2) summary

cd06937
Location:186 → 416

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:82 → 166

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
XM_047436508.1 → XP_047292464.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_047436506.1 → XP_047292462.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_005257553.2 → XP_005257610.1 retinoic acid receptor alpha isoform X1

See identical proteins and their annotated locations for XP_005257610.1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

A8K840, Q6I9R7

Conserved Domains (2) summary

cd06937
Location:186 → 416

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:82 → 166

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
XM_011525096.2 → XP_011523398.1 retinoic acid receptor alpha isoform X3

UniProtKB/TrEMBL

A8K840

Conserved Domains (2) summary

cd06937
Location:128 → 358

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:24 → 108

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
XM_005257552.6 → XP_005257609.1 retinoic acid receptor alpha isoform X2

See identical proteins and their annotated locations for XP_005257609.1

UniProtKB/TrEMBL

A8MUP8, B3KUX3

Related

ENSP00000377648.3, ENST00000394086.7

Conserved Domains (2) summary

cd06937
Location:202 → 432

NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

cd06964
Location:98 → 182

NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

41172682..41221155

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316839.1 → XP_054172814.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_054316840.1 → XP_054172815.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_054316838.1 → XP_054172813.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_054316841.1 → XP_054172816.1 retinoic acid receptor alpha isoform X1

UniProtKB/Swiss-Prot

B8Y636, P10276, P78456, Q9NQS0

UniProtKB/TrEMBL

Q6I9R7
XM_054316844.1 → XP_054172819.1 retinoic acid receptor alpha isoform X2

UniProtKB/TrEMBL

A8MUP8
XM_054316842.1 → XP_054172817.1 retinoic acid receptor alpha isoform X4
XM_054316843.1 → XP_054172818.1 retinoic acid receptor alpha isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033603.1: Suppressed sequence

Description

NM_001033603.1: This RefSeq was permanently suppressed because the 3'UTR is not supported and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.