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Dnase2b deoxyribonuclease 2 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 59296, updated on 11-Apr-2024

Summary

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Official Symbol
Dnase2bprovided by RGD
Official Full Name
deoxyribonuclease 2 betaprovided by RGD
Primary source
RGD:70901
See related
Ensembl:ENSRNOG00000016262 AllianceGenome:RGD:70901
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UOX; Dlad
Summary
Enables deoxyribonuclease II activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and extracellular region. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 39.3), Lung (RPKM 3.0) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
2q44
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238131182..238168041, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235470915..235515211, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252436363..252475506, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 5 Neighboring gene ribosome production factor 1 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene urate oxidase Neighboring gene uncharacterized LOC120100965 Neighboring gene sterile alpha motif domain containing 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcription of the rat liver uricase-encoding gene is regulated via a cis-acting element responsive to cAMP. Izuhara M, et al. Gene, 1995 Dec 29. PMID 8566790
  2. Cloning of a cDNA encoding a rat DNase II-like acid DNase. Tanuma S, et al. Biochem Biophys Res Commun, 1999 Nov 19. PMID 10558878
  3. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus. Goto K, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855332, Free PMC Article
  4. DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Shiokawa D, et al. Nucleic Acids Res, 1999 Oct 15. PMID 10497274, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribonuclease II activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deoxyribonuclease-2-beta
Names
DNA for uricase
DNase II beta
DNase II-like acid DNase
DNase2-like acid DNase
DNaseII-like acid DNase
deoxyribonuclease DLAD
deoxyribonuclease II beta
endonuclease DLAD
NP_067696.2
XP_017446549.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021664.2 → NP_067696.2  deoxyribonuclease-2-beta precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9QZK9
    UniProtKB/TrEMBL
    A6HWE1, G3V825
    Related
    ENSRNOP00000021861.2, ENSRNOT00000021861.5
    Conserved Domains (1) summary
    pfam03265
    Location:29 → 344
    DNase_II; Deoxyribonuclease II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    238131182..238168041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591060.3 → XP_017446549.1  deoxyribonuclease-2-beta isoform X1

    UniProtKB/Swiss-Prot
    Q9QZK9
    UniProtKB/TrEMBL
    A6HWE1, G3V825
    Conserved Domains (1) summary
    pfam03265
    Location:29 → 344
    DNase_II; Deoxyribonuclease II
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZK9.1 GenPept UniProtKB/Swiss-Prot:Q9QZK9

Gene LinkOut

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