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SIGIRR single Ig and TIR domain containing [ Homo sapiens (human) ]

Gene ID: 59307, updated on 3-Apr-2024

Summary

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Official Symbol
SIGIRRprovided by HGNC
Official Full Name
single Ig and TIR domain containingprovided by HGNC
Primary source
HGNC:HGNC:30575
See related
Ensembl:ENSG00000185187 MIM:605478; AllianceGenome:HGNC:30575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIR8; IL-1R8
Summary
Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (405716..417397, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (451081..462850, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (405716..417397, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:380111-380268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:393662-394424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:396383-396912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:405522-406215 Neighboring gene plakophilin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:415472-416091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:420870-421731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:428546-429745 Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC105376506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:434102-434620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3005 Neighboring gene Sharpr-MPRA regulatory region 223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:442612-443409 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:449779-450465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:454927-455648 Neighboring gene phosphatidylserine synthase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:460662-460845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:467161-467660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471334-471857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471858-472380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:476893-477888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:484337-484858 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:487868-488008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC. Mariotti FR, et al. Semin Immunol, 2023 Mar. PMID 36753974
  2. IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway. Jia C, et al. Cell Death Dis, 2021 Jun 3. PMID 34083516, Free PMC Article
  3. Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis. Yang X, et al. Biomed Res Int, 2021. PMID 34036103, Free PMC Article
  4. Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR. Al-Kuhlani M, et al. PLoS One, 2020. PMID 32210474, Free PMC Article
  5. Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR). Vilia MG, et al. Eur Cytokine Netw, 2017 Jun 1. PMID 28840837

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC.
    Title: IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC.
  2. SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
    Title: SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
  3. IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway.
    Title: IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway.
  4. Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis.
    Title: Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis.
  5. IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
    Title: IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
  6. Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro.
    Title: Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro.
  7. MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
    Title: MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
  8. Single immunoglobulin and Tollinterleukin1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Tolllike receptor4 signaling pathway: A clinical and experimental study.
    Title: Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study.
  9. The anti-inflammatory IL-37/SIGIRR axis is functionally compromised in HIV infection.
    Title: The anti-inflammatory IL-37/SIGIRR axis is functionally compromised in HIV infection.
  10. Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR
    Title: Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC110992

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of chemokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
single Ig IL-1-related receptor
Names
single Ig IL-1R-related molecule
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin domain IL1R1 related
single immunoglobulin domain-containing IL1R-related protein
toll/interleukin-1 receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135053.2 → NP_001128525.1  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_001128525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506, DA963481
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q3KQY2, Q6IA17, Q6UXI3, Q9H733
    UniProtKB/TrEMBL
    A0A291NLA3
    Related
    ENSP00000380756.3, ENST00000397632.7
    Conserved Domains (2) summary
    pfam01582
    Location:165 → 311
    TIR; TIR domain
    cl11960
    Location:8 → 111
    Ig; Immunoglobulin domain

  2. NM_001135054.2 → NP_001128526.1  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_001128526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506, DB112269
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q3KQY2, Q6IA17, Q6UXI3, Q9H733
    UniProtKB/TrEMBL
    A0A291NLA3
    Related
    ENSP00000403104.2, ENST00000431843.7
    Conserved Domains (2) summary
    pfam01582
    Location:165 → 311
    TIR; TIR domain
    cl11960
    Location:8 → 111
    Ig; Immunoglobulin domain

  3. NM_021805.3 → NP_068577.2  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_068577.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q3KQY2, Q6IA17, Q6UXI3, Q9H733
    UniProtKB/TrEMBL
    A0A291NLA3
    Related
    ENSP00000333656.3, ENST00000332725.7
    Conserved Domains (2) summary
    pfam01582
    Location:165 → 311
    TIR; TIR domain
    cl11960
    Location:8 → 111
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    405716..417397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427388.1 → XP_047283344.1  single Ig IL-1-related receptor isoform X2

  2. XM_005253045.1 → XP_005253102.1  single Ig IL-1-related receptor isoform X1

    See identical proteins and their annotated locations for XP_005253102.1

    UniProtKB/TrEMBL
    A0A291NLA3, C9JFX4
    Related
    ENSP00000433022.1, ENST00000531205.5
    Conserved Domains (2) summary
    pfam01582
    Location:165 → 311
    TIR; TIR domain
    cl11960
    Location:8 → 111
    Ig; Immunoglobulin domain

  3. XM_047427387.1 → XP_047283343.1  single Ig IL-1-related receptor isoform X2

  4. XM_005253046.2 → XP_005253103.1  single Ig IL-1-related receptor isoform X1

    See identical proteins and their annotated locations for XP_005253103.1

    UniProtKB/TrEMBL
    A0A291NLA3, C9JFX4
    Conserved Domains (2) summary
    pfam01582
    Location:165 → 311
    TIR; TIR domain
    cl11960
    Location:8 → 111
    Ig; Immunoglobulin domain

  5. XM_047427389.1 → XP_047283345.1  single Ig IL-1-related receptor isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    451081..462850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369598.1 → XP_054225573.1  single Ig IL-1-related receptor isoform X2

  2. XM_054369596.1 → XP_054225571.1  single Ig IL-1-related receptor isoform X1

    UniProtKB/TrEMBL
    C9JFX4

  3. XM_054369597.1 → XP_054225572.1  single Ig IL-1-related receptor isoform X2

  4. XM_054369595.1 → XP_054225570.1  single Ig IL-1-related receptor isoform X1

    UniProtKB/TrEMBL
    C9JFX4

  5. XM_054369599.1 → XP_054225574.1  single Ig IL-1-related receptor isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IA17.3 GenPept UniProtKB/Swiss-Prot:Q6IA17

Gene LinkOut

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