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Serpinb2 serpin family B member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60325, updated on 5-Mar-2024

Summary

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Official Symbol
Serpinb2provided by RGD
Official Full Name
serpin family B member 2provided by RGD
Primary source
RGD:621823
See related
Ensembl:ENSRNOG00000002460 AllianceGenome:RGD:621823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pai2a
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in wound healing. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human SERPINB2 (serpin family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 13.4), Spleen (RPKM 10.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
13p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (24051933..24065032)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (23537312..23551823)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (27449907..27463015)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 pseudogene 3 Neighboring gene serpin family B member 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serpin family B member 10 Neighboring gene serpin family B member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression of plasminogen activator system in a rat model of periodontal wound healing. Xiao Y, et al. J Periodontol, 2001 Jul. PMID 11495131
  2. Immunochemically detected placental proteins and their biological functions. Bohn H, et al. Arch Gynecol Obstet, 1991. PMID 1772263
  3. Basic mechanisms and regulation of fibrinolysis. Longstaff C, et al. J Thromb Haemost, 2015 Jun. PMID 26149056
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plasminogen activator inhibitor 2 type A
Names
PAI-2
serine (or cysteine) peptidase inhibitor, clade B, member 2
serine (or cysteine) proteinase inhibitor, clade B, member 2
serpin B2
serpin peptidase inhibitor, clade B (ovalbumin), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021696.2 → NP_067728.1  plasminogen activator inhibitor 2 type A

    See identical proteins and their annotated locations for NP_067728.1

    Status: PROVISIONAL

    Source sequence(s)
    X64563
    UniProtKB/Swiss-Prot
    P29524
    UniProtKB/TrEMBL
    A6JSV9
    Related
    ENSRNOP00000003409.4, ENSRNOT00000003409.6
    Conserved Domains (1) summary
    cd19562
    Location:2 → 416
    serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    24051933..24065032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769495.4 → XP_008767717.1  plasminogen activator inhibitor 2 type A isoform X1

    See identical proteins and their annotated locations for XP_008767717.1

    UniProtKB/Swiss-Prot
    P29524
    UniProtKB/TrEMBL
    A6JSV9
    Conserved Domains (1) summary
    cd19562
    Location:2 → 416
    serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2

  2. XM_006249639.5 → XP_006249701.1  plasminogen activator inhibitor 2 type A isoform X1

    See identical proteins and their annotated locations for XP_006249701.1

    UniProtKB/Swiss-Prot
    P29524
    UniProtKB/TrEMBL
    A6JSV9
    Conserved Domains (1) summary
    cd19562
    Location:2 → 416
    serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29524.1 GenPept UniProtKB/Swiss-Prot:P29524

Gene LinkOut

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