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Csad cysteine sulfinic acid decarboxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 60356, updated on 13-Apr-2024

Summary

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Official Symbol
Csadprovided by RGD
Official Full Name
cysteine sulfinic acid decarboxylaseprovided by RGD
Primary source
RGD:621030
See related
Ensembl:ENSRNOG00000011573 AllianceGenome:RGD:621030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables sulfinoalanine decarboxylase activity. Involved in L-cysteine catabolic process to hypotaurine and L-cysteine catabolic process to taurine. Located in cytoplasm. Orthologous to human CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 476.4), Kidney (RPKM 261.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135187175..135216495, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133308571..133337914, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143781520..143810880, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2 Neighboring gene zinc finger protein 740 Neighboring gene integrin subunit beta 7 Neighboring gene uncharacterized LOC134479582 Neighboring gene retinoic acid receptor, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the cDNA coding for rat brain cysteine sulfinate decarboxylase: brain and liver enzymes are identical proteins encoded by two distinct mRNAs. Tappaz M, et al. J Neurochem, 1999 Sep. PMID 10461879
  2. Cysteine sulfinate decarboxylase (CSD): molecular cloning, sequence and genomic expression in brain. Tappaz M, et al. Adv Exp Med Biol, 1998. PMID 9635011
  3. Immunocytochemical localization of cysteine sulfinate decarboxylase in astrocytes in the cerebellum and hippocampus: a quantitative double immunofluorescence study with glial fibrillary acidic protein and S-100 protein. Reymond I, et al. Neuroscience, 1996 Nov. PMID 8931024
  4. Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD). Reymond I, et al. Biochim Biophys Acta, 1996 Jun 7. PMID 8679699
  5. Cloning and characterization of rat cysteine sulfinic acid decarboxylase. Kaisaki PJ, et al. Biochim Biophys Acta, 1995 May 17. PMID 7772604

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartate 1-decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfinoalanine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfinoalanine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-cysteine catabolic process to hypotaurine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-cysteine catabolic process to taurine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in taurine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in taurine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cysteine sulfinic acid decarboxylase
Names
aspartate 1-decarboxylase
cysteine-sulfinate decarboxylase
sulfinoalanine decarboxylase
NP_068518.1
XP_006242500.1
XP_006242501.1
XP_006242502.1
XP_038935762.1
XP_038935763.1
XP_038935766.1
XP_063120254.1
XP_063120255.1
XP_063120256.1
XP_063120257.1
XP_063120258.1
XP_063120260.1
XP_063120261.1
XP_063120262.1
XP_063120263.1
XP_063120264.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021750.3 → NP_068518.1  cysteine sulfinic acid decarboxylase

    See identical proteins and their annotated locations for NP_068518.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Related
    ENSRNOP00000073508.2, ENSRNOT00000079678.2
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135187175..135216495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264193.1 → XP_063120263.1  cysteine sulfinic acid decarboxylase isoform X3

  2. XM_063264191.1 → XP_063120261.1  cysteine sulfinic acid decarboxylase isoform X3

  3. XM_039079838.2 → XP_038935766.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q7U2, B3VPA7
    Related
    ENSRNOP00000016205.5
    Conserved Domains (1) summary
    cd06450
    Location:68 → 468
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  4. XM_063264188.1 → XP_063120258.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q7U2

  5. XM_006242438.5 → XP_006242500.1  cysteine sulfinic acid decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006242500.1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  6. XM_006242440.5 → XP_006242502.1  cysteine sulfinic acid decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006242502.1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Related
    ENSRNOP00000080923.1
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  7. XM_063264184.1 → XP_063120254.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1

  8. XM_063264192.1 → XP_063120262.1  cysteine sulfinic acid decarboxylase isoform X3

  9. XM_039079835.2 → XP_038935763.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  10. XM_063264190.1 → XP_063120260.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q7U2

  11. XM_063264194.1 → XP_063120264.1  cysteine sulfinic acid decarboxylase isoform X3

  12. XM_006242439.4 → XP_006242501.1  cysteine sulfinic acid decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006242501.1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Related
    ENSRNOP00000087863.1
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  13. XM_063264186.1 → XP_063120256.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1

  14. XM_039079834.2 → XP_038935762.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1, B3VPA7
    Conserved Domains (1) summary
    cd06450
    Location:89 → 489
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  15. XM_063264187.1 → XP_063120257.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1

  16. XM_063264185.1 → XP_063120255.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q546T1, Q64577, Q64611, Q9R1F6
    UniProtKB/TrEMBL
    A6KCT1

RNA

  1. XR_010053037.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134454.1: Suppressed sequence

    Description
    NM_001134454.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64611.1 GenPept UniProtKB/Swiss-Prot:Q64611

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