U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trappc4 trafficking protein particle complex 4 [ Mus musculus (house mouse) ]

Gene ID: 60409, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Trappc4provided by MGI
Official Full Name
trafficking protein particle complex 4provided by MGI
Primary source
MGI:MGI:1926211
See related
Ensembl:ENSMUSG00000032112 AllianceGenome:MGI:1926211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sbd; Sbdn; TRS23; PTD009; Sdcbp2; HSPC172; 1500017G03Rik
Summary
Involved in dendrite development. Located in Golgi stack; dendrite; and synaptic vesicle. Part of TRAPP complex. Is expressed in central nervous system; ganglia; olfactory epithelium; thymus primordium; and tooth. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 46.5), CNS E14 (RPKM 40.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A5.2; 9 24.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44315057..44318629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44403755..44407548, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5063 Neighboring gene predicted gene, 26306 Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085 Neighboring gene STARR-positive B cell enhancer ABC_E2291 Neighboring gene ribosomal protein S25 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene STARR-seq mESC enhancer starr_23968 Neighboring gene forkhead box R1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. Kong X, et al. J Natl Cancer Inst, 2013 Nov 20. PMID 24104608, Free PMC Article
  2. Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Wang X, et al. Cells, 2020 May 4. PMID 32375403, Free PMC Article
  3. Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines. Ethell IM, et al. J Cell Biol, 2000 Oct 2. PMID 11018053, Free PMC Article
  4. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922
  5. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
    Title: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
  2. Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC.
    Title: Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPPII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
trafficking protein particle complex subunit 4
Names
TRS23 homolog
synbindin
syndecan binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417827.1 → NP_001404756.1  trafficking protein particle complex subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122428
    Related
    ENSMUST00000213747.2

  2. NM_021789.3 → NP_068561.1  trafficking protein particle complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_068561.1

    Status: VALIDATED

    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23109.1
    UniProtKB/Swiss-Prot
    Q9DB31, Q9ES56
    UniProtKB/TrEMBL
    Q3V493, Q544R8
    Related
    ENSMUSP00000034623.7, ENSMUST00000034623.8
    Conserved Domains (1) summary
    cd14856
    Location:4 → 205
    TRAPPC4_synbindin; Trafficking protein particle complex subunit 4

RNA

  1. NR_184635.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122428

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44315057..44318629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES56.1 GenPept UniProtKB/Swiss-Prot:Q9ES56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous