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Wtap Wilms tumour 1-associating protein [ Mus musculus (house mouse) ]

Gene ID: 60532, updated on 3-Jul-2021

Summary

Official Symbol
Wtapprovided by MGI
Official Full Name
Wilms tumour 1-associating proteinprovided by MGI
Primary source
MGI:MGI:1926395
See related
Ensembl:ENSMUSG00000060475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810408K05Rik; 9430038B09Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.6) and 28 other tissues See more
Orthologs
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Genomic context

See Wtap in Genome Data Viewer
Location:
17; 17 A1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13185686..13211430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12966799..12992543, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13159665..13185405, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946 Neighboring gene superoxide dismutase 2, mitochondrial Neighboring gene predicted gene, 36117

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pre-mRNA-splicing regulator WTAP
Names
WT1-associated protein
Wilms' tumour 1-associating protein
female-lethal(2)D homolog
wilms tumor 1-associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113532.1NP_001107004.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_001107004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
    Source sequence(s)
    AK031965, AK041341, BC093504, BY016042
    Consensus CDS
    CCDS49949.1
    UniProtKB/Swiss-Prot
    Q9ER69
    Related
    ENSMUSP00000123961.2, ENSMUST00000159986.8
    Conserved Domains (1) summary
    pfam17098
    Location:68150
    Wtap; WTAP/Mum2p family
  2. NM_001113533.1NP_001107005.1  pre-mRNA-splicing regulator WTAP isoform a

    See identical proteins and their annotated locations for NP_001107005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL589878
    Consensus CDS
    CCDS49950.1
    UniProtKB/TrEMBL
    E0CYH0
    Related
    ENSMUSP00000007007.8, ENSMUST00000007007.14
    Conserved Domains (1) summary
    pfam17098
    Location:68222
    Wtap; WTAP/Mum2p family
  3. NM_001379058.1NP_001365987.1  pre-mRNA-splicing regulator WTAP isoform a

    Status: VALIDATED

    Source sequence(s)
    AL589878
    Related
    ENSMUSP00000124205.2, ENSMUST00000159551.8
    Conserved Domains (1) summary
    pfam17098
    Location:68222
    Wtap; WTAP/Mum2p family
  4. NM_175394.2NP_780603.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_780603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' UTR exon and lacks two exons, and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
    Source sequence(s)
    AK031965, AK041341, AK076111
    Consensus CDS
    CCDS49949.1
    UniProtKB/Swiss-Prot
    Q9ER69
    Related
    ENSMUSP00000124138.2, ENSMUST00000160781.8
    Conserved Domains (1) summary
    pfam17098
    Location:68150
    Wtap; WTAP/Mum2p family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13185686..13211430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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