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Napsa napsin A aspartic peptidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 60575, updated on 5-Mar-2024

Summary

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Official Symbol
Napsaprovided by RGD
Official Full Name
napsin A aspartic peptidaseprovided by RGD
Primary source
RGD:61940
See related
Ensembl:ENSRNOG00000019854 AllianceGenome:RGD:61940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kdap
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in membrane protein proteolysis and surfactant homeostasis. Predicted to be located in alveolar lamellar body and extracellular space. Predicted to be active in lysosome. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1553.1), Lung (RPKM 581.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
1q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104200967..104213603)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95064726..95077101)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100577497..100589802)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 1, catalytic subunit Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene potassium voltage-gated channel subfamily C member 3 Neighboring gene myosin heavy chain 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, expression and functional characterization of rat napsin. Schauer-Vukasinovic V, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858550
  2. Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation. Niderla-Bielińska J, et al. Folia Histochem Cytobiol, 2011. PMID 21744336
  3. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. Woischnik M, et al. Eur Respir J, 2008 Jun. PMID 18216060
  4. Processing of pulmonary surfactant protein B by napsin and cathepsin H. Ueno T, et al. J Biol Chem, 2004 Apr 16. PMID 14766755
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The level of mRNA for differentiation markers: involucrin, filaggrin, keratinocyte differentiation associated protein and trichohyalin, was studied by RealTime PCR.
    Title: Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
napsin-A
Names
kidney-derived aspartic protease-like protein
NP_113858.1
XP_038944991.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031670.2 → NP_113858.1  napsin-A precursor

    See identical proteins and their annotated locations for NP_113858.1

    Status: VALIDATED

    Source sequence(s)
    BC078790, CB809217
    UniProtKB/TrEMBL
    A6JAR3, F7FL28, Q68G15, Q9QX71
    Related
    ENSRNOP00000026992.5, ENSRNOT00000026992.7
    Conserved Domains (2) summary
    pfam00026
    Location:73 → 397
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:69 → 395
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104200967..104213603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089063.2 → XP_038944991.1  napsin-A isoform X1

    Conserved Domains (1) summary
    cl11403
    Location:70 → 314
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version

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