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Unc5a unc-5 netrin receptor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 60629, updated on 6-May-2021

Summary

Official Symbol
Unc5aprovided by RGD
Official Full Name
unc-5 netrin receptor Aprovided by RGD
Primary source
RGD:621755
See related
Ensembl:ENSRNOG00000059840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Unc5h1
Summary
a netrin receptor involved in neuronal migration [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 33.6), Adrenal (RPKM 7.7) and 6 other tissues See more
Orthologs
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Genomic context

See Unc5a in Genome Data Viewer
Location:
17p14
Exon count:
16
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9614841..9670558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10152949..10208599, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene hexokinase 3 Neighboring gene uncharacterized LOC120097834 Neighboring gene uncharacterized LOC102550792

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables netrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anterior/posterior axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anterior/posterior axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in netrin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuronal cell body membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin receptor UNC5A
Names
protein unc-5 homolog 1
protein unc-5 homolog A
transmembrane receptor Unc5H1
unc-5 homolog 1
unc-5 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022206.1NP_071542.1  netrin receptor UNC5A precursor

    See identical proteins and their annotated locations for NP_071542.1

    Status: PROVISIONAL

    Source sequence(s)
    U87305
    UniProtKB/Swiss-Prot
    O08721
    Related
    ENSRNOP00000071115.1, ENSRNOT00000087397.1
    Conserved Domains (5) summary
    smart00218
    Location:495598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:811894
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    9614841..9670558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771505.2XP_008769727.1  netrin receptor UNC5A isoform X1

    Conserved Domains (5) summary
    smart00218
    Location:439542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:254293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:755838
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153239
    Ig; Immunoglobulin domain

RNA

  1. XR_005495326.1 RNA Sequence

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