DMD dystrophin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DMDprovided by VGNC
Official Full Name: dystrophinprovided by VGNC
Primary source: VGNC:VGNC:54134
See related: Ensembl:ENSCAFG00845017750
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 86

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	X	NC_051843.1 (26319830..28487633, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	X	NC_006621.4 (31264482..33330008, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	X	NC_049260.1 (26455978..28540050, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	X	NC_049299.1 (26365124..28433100, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	X	NC_049780.1 (26358103..28426635, complement)

Chromosome X - NC_051843.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.
Title: Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.
Protein Expression of Canine and Feline Muscular Dystrophies.
Title: Protein Expression of Canine and Feline Muscular Dystrophies.
The deletion was confirmed with conventional PCR and Sanger sequencing. This mutation is in a secondary DMD gene hotspot area distinct from the one identified earlier at the 5' donor splice site of intron 50 in the CKCS breed.
Title: Whole genome sequencing reveals a 7 base-pair deletion in DMD exon 42 in a dog with muscular dystrophy.
Partial myostatin loss may exaggerate selective muscle hypertrophy or atrophy/hypoplasia in dystrophin-deficient dogs and worsen contractures.
Title: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.
a chromosome inversion disrupting the DMD and RPGR genes is the causative mutation for X-linked muscular dystrophy in the Japanese Spitz breed
Title: Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Data indicate that dystrophin affects caveolar integrity and airway smooth muscle contraction.
Title: Role of dystrophin in airway smooth muscle phenotype, contraction and lung function.
These data are consistent with the notion that altered N-glycolylneuraminic acid and cytotoxic T cell carbohydrate expression may modify severity of muscular dystrophy resulting from dystrophin deficiency in dogs and humans.
Title: A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.
These data underscore the muscle-specific responses to dystrophin deficiency and the potential deleterious effects of differential muscle involvement.
Title: Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs.
Data indicate extensive expression of skipped RNA and dystrophin protein in the treated myocardium.
Title: MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy.
eccentric contractions induce greater-than-normal isometric torque drop in dystrophin-deficient dog muscles
Title: Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

DMD (e-PCR)
- UniSTS:99343

BAC_385-G21 (e-PCR)
- UniSTS:262698

PMC108984P1 (e-PCR)
- UniSTS:270148

MARC_84337-84338:1278013457:1 (e-PCR)
- UniSTS:532589

MARC_84339-84340:1278014518:1 (e-PCR)
- UniSTS:532590

MARC_84357-84358:1278016549:1 (e-PCR)
- UniSTS:532591

DXS1234 (e-PCR)
- UniSTS:146800

PMC316713P2 (e-PCR)
- UniSTS:273040

DMD (e-PCR)
- UniSTS:99474

DMD (e-PCR)
- UniSTS:506537

DMD (e-PCR)
- UniSTS:99541

L77299 (e-PCR)
- UniSTS:12797

DMD (e-PCR)
- UniSTS:99582

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in synaptic signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dystrophin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003343.1 → NP_001003343.1 dystrophin

See identical proteins and their annotated locations for NP_001003343.1

Status: PROVISIONAL

Source sequence(s)

AF070485

UniProtKB/Swiss-Prot

O97592

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Related

ENSCAFP00845027617.1, ENSCAFT00845035278.1

Conserved Domains (10) summary

COG1340
Location:1706 → 1976

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00014
Location:16 → 119

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3054 → 3083

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3306 → 3354

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00435
Location:2929 → 3035

Spectrin; Spectrin repeat

pfam09068
Location:3084 → 3202

EF-hand_2; EF hand

pfam09069
Location:3206 → 3297

EF-hand_3; EF-hand

pfam16769
Location:3483 → 3666

MCM3AP_GANP; MCM3AP domain of GANP

cl02488
Location:1469 → 1678

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051843.1 Reference ROS_Cfam_1.0

Range

26319830..28487633 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038448876.1 → XP_038304804.1 dystrophin isoform X3

UniProtKB/TrEMBL

A0A8I3P842

Conserved Domains (9) summary

cd00176
Location:337 → 551

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3046 → 3075

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3298 → 3346

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1120 → 1930

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3112 → 3273

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2921 → 3027

Spectrin; Spectrin repeat

cd21231
Location:3 → 113

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:128 → 238

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:553 → 820

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448883.1 → XP_038304811.1 dystrophin isoform X10

UniProtKB/TrEMBL

A0A8I3P842

Conserved Domains (8) summary

cd00176
Location:222 → 436

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2930 → 2959

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3182 → 3230

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1005 → 1815

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:2996 → 3157

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2805 → 2911

Spectrin; Spectrin repeat

cd21233
Location:13 → 123

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:438 → 705

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448880.1 → XP_038304808.1 dystrophin isoform X7

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:301 → 515

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3010 → 3039

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3262 → 3310

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1084 → 1894

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3076 → 3237

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2885 → 2991

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:517 → 784

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448881.1 → XP_038304809.1 dystrophin isoform X8

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3008 → 3037

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3260 → 3308

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1925

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3074 → 3235

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2883 → 2989

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448875.1 → XP_038304803.1 dystrophin isoform X2

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3053 → 3082

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3305 → 3353

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3119 → 3280

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2928 → 3034

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448878.1 → XP_038304806.1 dystrophin isoform X5

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3053 → 3082

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3305 → 3353

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3119 → 3280

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2928 → 3034

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448877.1 → XP_038304805.1 dystrophin isoform X4

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3054 → 3083

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3306 → 3354

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3120 → 3281

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2929 → 3035

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448879.1 → XP_038304807.1 dystrophin isoform X6

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3054 → 3083

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3306 → 3354

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3120 → 3281

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2929 → 3035

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448874.1 → XP_038304802.1 dystrophin isoform X1

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (9) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:3054 → 3083

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3306 → 3354

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:3120 → 3281

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2929 → 3035

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 828

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448882.1 → XP_038304810.1 dystrophin isoform X9

UniProtKB/TrEMBL

A0A8I3P842

Conserved Domains (8) summary

cd00176
Location:222 → 436

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2931 → 2960

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3183 → 3231

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:1005 → 1815

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:2997 → 3158

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2806 → 2912

Spectrin; Spectrin repeat

cd21233
Location:13 → 123

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:438 → 705

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448884.1 → XP_038304812.1 dystrophin isoform X11

UniProtKB/TrEMBL

A0A8I3P842

Conserved Domains (8) summary

cd00176
Location:131 → 345

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2840 → 2869

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3092 → 3140

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:914 → 1724

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:2906 → 3067

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2715 → 2821

Spectrin; Spectrin repeat

cl00030
Location:2 → 32

CH_SF; calponin homology (CH) domain superfamily

cl02488
Location:347 → 614

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448885.1 → XP_038304813.1 dystrophin isoform X12

UniProtKB/TrEMBL

A0A8I3P842

Conserved Domains (8) summary

cd00176
Location:116 → 330

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2825 → 2854

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3077 → 3125

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:899 → 1709

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16246
Location:2891 → 3052

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:2700 → 2806

Spectrin; Spectrin repeat

cl00030
Location:1 → 17

CH_SF; calponin homology (CH) domain superfamily

cl02488
Location:332 → 599

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_038448887.1 → XP_038304815.1 dystrophin isoform X14

UniProtKB/TrEMBL

A0A8I3P9H1, A0A8P0T489

Related

ENSCAFP00845026508.1, ENSCAFT00845033876.1

Conserved Domains (6) summary

COG1196
Location:975 → 1145

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:230 → 473

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:599 → 628

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:851 → 899

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:665 → 826

EFh_DMD; EF-hand-like motif found in dystrophin

pfam00435
Location:474 → 580

Spectrin; Spectrin repeat
XM_038448889.1 → XP_038304817.1 dystrophin isoform X16

UniProtKB/TrEMBL

A0A8C0RQN8

Conserved Domains (3) summary

COG1196
Location:354 → 524

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin
XM_038448891.1 → XP_038304819.1 dystrophin isoform X18

UniProtKB/TrEMBL

A0A8C0RQN8

Conserved Domains (3) summary

COG1196
Location:354 → 524

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin
XM_038448888.1 → XP_038304816.1 dystrophin isoform X15

UniProtKB/TrEMBL

A0A8C0RQN8

Conserved Domains (3) summary

COG1196
Location:367 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin
XM_038448890.1 → XP_038304818.1 dystrophin isoform X17

UniProtKB/TrEMBL

A0A8C0RQN8, A0A8C0SQ31

Conserved Domains (3) summary

COG1196
Location:367 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd02334
Location:243 → 291

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16246
Location:57 → 218

EFh_DMD; EF-hand-like motif found in dystrophin
XM_038448886.1 → XP_038304814.1 dystrophin isoform X13

UniProtKB/TrEMBL

A0A8I3PK93, A0A8P0NLV2

Conserved Domains (6) summary

cd00176
Location:345 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1128 → 1938

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00435
Location:2929 → 3023

Spectrin; Spectrin repeat

cd21231
Location:11 → 121

CH_DMD_rpt1; first calponin homology (CH) domain found in dystrophin and similar proteins

cd21233
Location:136 → 246

CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins

cl02488
Location:561 → 781

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...