PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PCBD1provided by VGNC
Official Full Name: pterin-4 alpha-carbinolamine dehydratase 1provided by VGNC
Primary source: VGNC:VGNC:44291
See related: Ensembl:ENSCAFG00845004424
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (21997912..22002345, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (21854056..21858488, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (22451020..22455453, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (21893535..21897967, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (22098728..22103182, complement)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

MARC_2924-2925:991933743:1 (e-PCR)
- UniSTS:230980

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pterin-4-alpha-carbinolamine dehydratase

Names: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)

XP_005619043.1

EC 4.2.1.96

XP_038329115.1

EC 4.2.1.96

XP_038329116.1

EC 4.2.1.96

XP_038346826.1

EC 4.2.1.96

XP_038390176.1

EC 4.2.1.96

XP_038390177.1

EC 4.2.1.96

XP_038454492.1

EC 4.2.1.96

XP_038454493.1

EC 4.2.1.96

XP_038518762.1

EC 4.2.1.96

XP_038518763.1

EC 4.2.1.96

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051808.1 Reference ROS_Cfam_1.0

Range

21997912..22002345 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038662835.1 → XP_038518763.1 pterin-4-alpha-carbinolamine dehydratase isoform X2

UniProtKB/TrEMBL

A0A8C0N3X8, A0A8I3MQ42

Related

ENSCAFP00845006259.1, ENSCAFT00845007941.1

Conserved Domains (1) summary

cd00914
Location:24 → 99

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
XM_038662834.1 → XP_038518762.1 pterin-4-alpha-carbinolamine dehydratase isoform X1

UniProtKB/TrEMBL

A0A8C0R7X8

Conserved Domains (1) summary

cd00914
Location:27 → 102

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049264.1 Alternate UMICH_Zoey_3.1

Range

21893535..21897967 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038473188.1 → XP_038329116.1 pterin-4-alpha-carbinolamine dehydratase isoform X2

Conserved Domains (1) summary

cd00914
Location:24 → 99

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
XM_038473187.1 → XP_038329115.1 pterin-4-alpha-carbinolamine dehydratase isoform X1

Conserved Domains (1) summary

cd00914
Location:27 → 102

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049745.1 Alternate UNSW_CanFamBas_1.0

Range

22098728..22103182 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038598565.1 → XP_038454493.1 pterin-4-alpha-carbinolamine dehydratase isoform X2

Conserved Domains (1) summary

cd00914
Location:24 → 99

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
XM_038598564.1 → XP_038454492.1 pterin-4-alpha-carbinolamine dehydratase isoform X1

Conserved Domains (1) summary

cd00914
Location:27 → 102

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049225.1 Alternate UU_Cfam_GSD_1.0

Range

22451020..22455453 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038534249.1 → XP_038390177.1 pterin-4-alpha-carbinolamine dehydratase isoform X2

UniProtKB/TrEMBL

A0A8C0N3X8, A0A8I3MQ42

Conserved Domains (1) summary

cd00914
Location:24 → 99

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
XM_038534248.1 → XP_038390176.1 pterin-4-alpha-carbinolamine dehydratase isoform X1

UniProtKB/TrEMBL

A0A8C0R7X8

Conserved Domains (1) summary

cd00914
Location:27 → 102

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

21854056..21858488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038490898.1 → XP_038346826.1 pterin-4-alpha-carbinolamine dehydratase isoform X2

UniProtKB/TrEMBL

A0A8C0N3X8, A0A8I3MQ42

Conserved Domains (1) summary

cd00914
Location:24 → 99

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
XM_005618986.4 → XP_005619043.1 pterin-4-alpha-carbinolamine dehydratase isoform X1

UniProtKB/TrEMBL

A0A8C0R7X8

Conserved Domains (1) summary

cd00914
Location:27 → 102

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...