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HNF1B HNF1 homeobox B [ Canis lupus familiaris (dog) ]

Gene ID: 610402, updated on 5-Mar-2024

Summary

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Official Symbol
HNF1Bprovided by VGNC
Official Full Name
HNF1 homeobox Bprovided by VGNC
Primary source
VGNC:VGNC:41724
See related
Ensembl:ENSCAFG00845008106
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
TCF2
Orthologs
human mouse all
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Genomic context

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See HNF1B in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (38248175..38303484, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (36661511..36717034, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (37403808..37459176, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (37029129..37084643, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (37316583..37372144, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene protein LZIC-like Neighboring gene prefoldin subunit 1-like Neighboring gene uncharacterized LOC106559307 Neighboring gene uncharacterized LOC111097420 Neighboring gene HEAT repeat containing 6 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte nuclear factor 1-beta
Names
hepatocyte nuclear factor 1-beta-like
transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    38248175..38303484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677284.1 → XP_038533212.1  hepatocyte nuclear factor 1-beta isoform X5

    UniProtKB/TrEMBL
    A0A8C0P4I4, A0A8I3N601
    Related
    ENSCAFP00845011226.1, ENSCAFT00845014489.1
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 426
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. XM_038677279.1 → XP_038533207.1  hepatocyte nuclear factor 1-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0P2E8, A0A8C0Q905, A0A8C0QUQ3, A0A8I3N2W6, A0A8I3N7U6
    Related
    ENSCAFP00845011148.1, ENSCAFT00845014396.1
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_038677283.1 → XP_038533211.1  hepatocyte nuclear factor 1-beta isoform X4

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. XM_038677280.1 → XP_038533208.1  hepatocyte nuclear factor 1-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Related
    ENSCAFP00845011199.1, ENSCAFT00845014457.1
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. XM_038677281.1 → XP_038533209.1  hepatocyte nuclear factor 1-beta isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_005432409.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    37029129..37084643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486250.1 → XP_038342178.1  hepatocyte nuclear factor 1-beta isoform X5

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 426
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. XM_038486245.1 → XP_038342173.1  hepatocyte nuclear factor 1-beta isoform X1

    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_038486248.1 → XP_038342176.1  hepatocyte nuclear factor 1-beta isoform X4

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. XM_038486246.1 → XP_038342174.1  hepatocyte nuclear factor 1-beta isoform X2

    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. XM_038486247.1 → XP_038342175.1  hepatocyte nuclear factor 1-beta isoform X3

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_005330947.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    37316583..37372144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612035.1 → XP_038467963.1  hepatocyte nuclear factor 1-beta isoform X5

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 426
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. XM_038612031.1 → XP_038467959.1  hepatocyte nuclear factor 1-beta isoform X1

    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_038612034.1 → XP_038467962.1  hepatocyte nuclear factor 1-beta isoform X4

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. XM_038612032.1 → XP_038467960.1  hepatocyte nuclear factor 1-beta isoform X2

    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. XM_038612033.1 → XP_038467961.1  hepatocyte nuclear factor 1-beta isoform X3

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_005399081.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    37403808..37459176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548066.1 → XP_038403994.1  hepatocyte nuclear factor 1-beta isoform X5

    UniProtKB/TrEMBL
    A0A8C0P4I4, A0A8I3N601
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 426
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. XM_038548062.1 → XP_038403990.1  hepatocyte nuclear factor 1-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0P2E8, A0A8C0Q905, A0A8C0QUQ3, A0A8I3N2W6, A0A8I3N7U6
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_038548065.1 → XP_038403993.1  hepatocyte nuclear factor 1-beta isoform X4

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. XM_038548063.1 → XP_038403991.1  hepatocyte nuclear factor 1-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. XM_038548064.1 → XP_038403992.1  hepatocyte nuclear factor 1-beta isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_005364644.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    36661511..36717034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014116744.3 → XP_013972219.1  hepatocyte nuclear factor 1-beta isoform X5

    UniProtKB/TrEMBL
    A0A8C0P4I4, A0A8I3N601
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 426
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. XM_005624790.4 → XP_005624847.1  hepatocyte nuclear factor 1-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0P2E8, A0A8C0Q905, A0A8C0QUQ3, A0A8I3N2W6, A0A8I3N7U6
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_003435293.4 → XP_003435341.1  hepatocyte nuclear factor 1-beta isoform X4

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. XM_847901.5 → XP_852994.2  hepatocyte nuclear factor 1-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. XM_005624791.3 → XP_005624848.1  hepatocyte nuclear factor 1-beta isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q905, A0A8I3N2W6
    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
    pfam04814
    Location:8 → 174
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. XR_002630073.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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