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MMP12 matrix metallopeptidase 12 [ Canis lupus familiaris (dog) ]

Gene ID: 611789, updated on 5-Mar-2024

Summary

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Official Symbol
MMP12provided by VGNC
Official Full Name
matrix metallopeptidase 12provided by VGNC
Primary source
VGNC:VGNC:43275
See related
Ensembl:ENSCAFG00845000798
Gene type
protein coding
RefSeq status
INFERRED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (28944813..28984612)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (28867153..28881802)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (29059239..29073925)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (29004848..29019524)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (28884303..28898943)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 5 Neighboring gene matrix metallopeptidase 13 Neighboring gene matrix metallopeptidase 3 (stromelysin 1, progelatinase) Neighboring gene matrix metallopeptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
macrophage metalloelastase
Names
macrophage elastase
NP_001274067.1
XP_038520153.1
XP_038520154.1
XP_038520155.1
XP_038520156.1
XP_038520157.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287138.1 → NP_001274067.1  macrophage metalloelastase precursor

    See identical proteins and their annotated locations for NP_001274067.1

    Status: INFERRED

    Source sequence(s)
    JAAUVH010000371
    UniProtKB/TrEMBL
    A0A8C0Z2Z1, A0A8I3MBX9
    Related
    ENSCAFP00845001037.1, ENSCAFT00845001346.1
    Conserved Domains (4) summary
    cd00094
    Location:282 → 455
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:110 → 264
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:110 → 264
    Peptidase_M10; Matrixin
    pfam01471
    Location:29 → 88
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    28944813..28984612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664227.1 → XP_038520155.1  macrophage metalloelastase isoform X3

    Conserved Domains (3) summary
    cd00094
    Location:237 → 410
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:65 → 219
    Peptidase_M10; Matrixin
    pfam01471
    Location:10 → 43
    PG_binding_1; Putative peptidoglycan binding domain

  2. XM_038664229.1 → XP_038520157.1  macrophage metalloelastase isoform X3

    Conserved Domains (3) summary
    cd00094
    Location:237 → 410
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:65 → 219
    Peptidase_M10; Matrixin
    pfam01471
    Location:10 → 43
    PG_binding_1; Putative peptidoglycan binding domain

  3. XM_038664228.1 → XP_038520156.1  macrophage metalloelastase isoform X3

    Conserved Domains (3) summary
    cd00094
    Location:237 → 410
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:65 → 219
    Peptidase_M10; Matrixin
    pfam01471
    Location:10 → 43
    PG_binding_1; Putative peptidoglycan binding domain

  4. XM_038664225.1 → XP_038520153.1  macrophage metalloelastase isoform X1

    Conserved Domains (3) summary
    cd00094
    Location:383 → 556
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:211 → 365
    Peptidase_M10; Matrixin
    pfam01471
    Location:135 → 189
    PG_binding_1; Putative peptidoglycan binding domain

  5. XM_038664226.1 → XP_038520154.1  macrophage metalloelastase isoform X2

    UniProtKB/TrEMBL
    A0A8C0QY83, A0A8C0T9C3, A0A8I3MX21
    Related
    ENSCAFP00845001018.1, ENSCAFT00845001320.1
    Conserved Domains (3) summary
    cd00094
    Location:303 → 476
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:131 → 285
    Peptidase_M10; Matrixin
    pfam01471
    Location:55 → 109
    PG_binding_1; Putative peptidoglycan binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    29004848..29019524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    28884303..28898943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    29059239..29073925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28867153..28881802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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