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PDHB pyruvate dehydrogenase E1 subunit beta [ Bos taurus (cattle) ]

Gene ID: 613610, updated on 11-Apr-2024

Summary

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Official Symbol
PDHBprovided by VGNC
Official Full Name
pyruvate dehydrogenase E1 subunit betaprovided by VGNC
Primary source
VGNC:VGNC:49151
See related
BGD:BT14411; Ensembl:ENSBTAG00000021724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PDHB in Genome Data Viewer
Location:
chromosome: 22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (42918475..42923888)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase 2 Neighboring gene potassium channel tetramerization domain containing 6 Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene U6 spliceosomal RNA Neighboring gene abhydrolase domain containing 6, acylglycerol lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular Characterization and Transcriptional Regulation Analysis of the Bovine PDHB Gene. Li A, et al. PLoS One, 2016. PMID 27379520, Free PMC Article
  2. Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex. Ho L, et al. Biochem Biophys Res Commun, 1988 Feb 15. PMID 2829898
  3. Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes. Yamada T, et al. Res Commun Mol Pathol Pharmacol, 2007-2008. PMID 21469508
  4. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
  5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the pyruvate dehydrogenase-E1 beta core promoter to be located 490bp upstream from the transcription initiation site (+1).
    Title: Molecular Characterization and Transcriptional Regulation Analysis of the Bovine PDHB Gene.
  2. Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
    Title: Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Names
PDHE1-B
pyruvate dehydrogenase (lipoamide) beta
pyruvate dehydrogenase E1 beta subunit
NP_001030512.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035435.3 → NP_001030512.2  pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001030512.2

    Status: PROVISIONAL

    Source sequence(s)
    BC150020
    UniProtKB/Swiss-Prot
    A6QQW6, P11966, Q58CN6
    UniProtKB/TrEMBL
    A0A3Q1MTX8
    Related
    ENSBTAP00000028958.4, ENSBTAT00000028958.6
    Conserved Domains (3) summary
    cd07036
    Location:37 → 203
    TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
    PLN02683
    Location:7 → 356
    PLN02683; pyruvate dehydrogenase E1 component subunit beta
    pfam02780
    Location:226 → 349
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42918475..42923888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11966.2 GenPept UniProtKB/Swiss-Prot:P11966

Gene LinkOut

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