SERPINA3-3 endopin 1b [Bos taurus (cattle)] - Gene

Summary

Gene symbol: SERPINA3-3
Gene description: endopin 1b
See related: BGD:BT15603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: SERPINA3-4
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Genomic context

Location:: chromosome: 21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (59385345..59392766, complement)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this report, by site-directed mutagenesis of recombinant SERPINA3-3, with substitution D371A, the study demonstrates the importance of D371 for the intermolecular linkage observed in denaturing and reducing conditions.
Title: Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimers.
Data demonstrate the strong inhibition of human initiator and effector caspases 3 and 8 by bovine SERPINA3-1 and A3-3.
Title: Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serpin A3-3

Names: Serpin A3-4; endopin-1B; mEndopin-1B; muscle endopin-1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038204.2 → NP_001033293.1 serpin A3-3 precursor

See identical proteins and their annotated locations for NP_001033293.1

Status: PROVISIONAL

Source sequence(s)

BC111356

UniProtKB/Swiss-Prot

A2I7N0, Q2T9M2, Q3ZEJ6

Conserved Domains (1) summary

cd02056
Location:46 → 405

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

Range

59385345..59392766 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024981936.2 → XP_024837704.1 serpin A3-3 isoform X1

UniProtKB/Swiss-Prot

A2I7N0

Conserved Domains (1) summary

cd02056
Location:60 → 419

alpha-1-antitrypsin_like; This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, kallistatin, and noninhibitory ...
XM_024981938.2 → XP_024837706.1 serpin A3-3 isoform X2

UniProtKB/Swiss-Prot

A2I7N0

UniProtKB/TrEMBL

G3N1U4

Conserved Domains (1) summary

cd02056
Location:46 → 405

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...