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RPL32 ribosomal protein L32 [ Homo sapiens (human) ]

Gene ID: 6161, updated on 11-Apr-2024

Summary

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Official Symbol
RPL32provided by HGNC
Official Full Name
ribosomal protein L32provided by HGNC
Primary source
HGNC:HGNC:10336
See related
Ensembl:ENSG00000144713 AllianceGenome:HGNC:10336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L32; eL32; PP9932
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 460.1), bone marrow (RPKM 265.8) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL32 in Genome Data Viewer
Location:
3p25.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12834485..12841582, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12835994..12843091, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12875984..12883081, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12779747-12780569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14067 Neighboring gene transmembrane protein 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12800761-12801346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14069 Neighboring gene keratin 18 pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12845071-12845571 Neighboring gene cullin associated and neddylation dissociated 2 (putative) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14070 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12855381-12855561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12871622-12872570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12881424-12882362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12882363-12883299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19454 Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene uncharacterized LOC124909346 Neighboring gene microtubule affinity regulating kinase 4 pseudogene Neighboring gene microtubule affinity regulating kinase 3 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biological effect of ribosomal protein L32 on human breast cancer cell behavior. Xu L, et al. Mol Med Rep, 2020 Sep. PMID 32705264, Free PMC Article
  2. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. Vorobieva NV, et al. Cytogenet Cell Genet, 1997. PMID 9284913
  3. An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease. Rutkowski D, et al. Br J Dermatol, 2015 Sep. PMID 25712143, Free PMC Article
  4. Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters. Baumbusch LO, et al. Mol Cancer, 2006 Oct 20. PMID 17054774, Free PMC Article
  5. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. Young JA, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3866218, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biological effect of ribosomal protein L32 on human breast cancer cell behavior.
    Title: Biological effect of ribosomal protein L32 on human breast cancer cell behavior.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein L32 (RPL32), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL32
Names
60S ribosomal protein L32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000994.4 → NP_000985.1  large ribosomal subunit protein eL32

    See identical proteins and their annotated locations for NP_000985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, CA436299, CF124158
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    B2R4Q3, P02433, P62910
    UniProtKB/TrEMBL
    D3YTB1
    Related
    ENSP00000416429.2, ENST00000429711.7
    Conserved Domains (1) summary
    pfam01655
    Location:17 → 124
    Ribosomal_L32e; Ribosomal protein L32

  2. NM_001007073.1 → NP_001007074.1  large ribosomal subunit protein eL32

    See identical proteins and their annotated locations for NP_001007074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, BQ068496, CA436299, CF124158
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    B2R4Q3, P02433, P62910
    UniProtKB/TrEMBL
    D3YTB1
    Related
    ENSP00000380158.1, ENST00000396957.5
    Conserved Domains (1) summary
    pfam01655
    Location:17 → 124
    Ribosomal_L32e; Ribosomal protein L32

  3. NM_001007074.1 → NP_001007075.1  large ribosomal subunit protein eL32

    See identical proteins and their annotated locations for NP_001007075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon but has an alternate segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, BC070209, BF960792, CA436299
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    B2R4Q3, P02433, P62910
    UniProtKB/TrEMBL
    D3YTB1
    Related
    ENSP00000380156.2, ENST00000396953.6
    Conserved Domains (1) summary
    pfam01655
    Location:17 → 124
    Ribosomal_L32e; Ribosomal protein L32

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    12834485..12841582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    12835994..12843091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62910.2 GenPept UniProtKB/Swiss-Prot:P62910

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