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Rgs22 regulator of G-protein signalling 22 [ Mus musculus (house mouse) ]

Gene ID: 626596, updated on 12-May-2024

Summary

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Official Symbol
Rgs22provided by MGI
Official Full Name
regulator of G-protein signalling 22provided by MGI
Primary source
MGI:MGI:3613651
See related
Ensembl:ENSMUSG00000037627 AllianceGenome:MGI:3613651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within negative regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in brain; reproductive system; respiratory system; and submandibular gland. Orthologous to human RGS22 (regulator of G protein signaling 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.4) and lung adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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See Rgs22 in Genome Data Viewer
Location:
15 B3.1; 15 14.46 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (35960664..36140718, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (35960508..36140572, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13B Neighboring gene predicted gene, 41292 Neighboring gene STARR-seq mESC enhancer starr_38348 Neighboring gene STARR-seq mESC enhancer starr_38349 Neighboring gene STARR-seq mESC enhancer starr_38350 Neighboring gene STARR-seq mESC enhancer starr_38351 Neighboring gene cytochrome c oxidase subunit 6C Neighboring gene STARR-seq mESC enhancer starr_38352 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene predicted gene, 22979 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K Neighboring gene sperm associated antigen 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195748.1 → NP_001182677.1  regulator of G-protein signaling 22

    See identical proteins and their annotated locations for NP_001182677.1

    Status: VALIDATED

    Source sequence(s)
    AC121577, AC157521, AC166820
    Consensus CDS
    CCDS56979.1
    UniProtKB/Swiss-Prot
    G3UYX5
    Related
    ENSMUSP00000134259.2, ENSMUST00000172831.8
    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    35960664..36140718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245372.4 → XP_011243674.1  regulator of G-protein signaling 22 isoform X1

    See identical proteins and their annotated locations for XP_011243674.1

    UniProtKB/Swiss-Prot
    G3UYX5
    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. XM_011245371.4 → XP_011243673.1  regulator of G-protein signaling 22 isoform X1

    See identical proteins and their annotated locations for XP_011243673.1

    UniProtKB/Swiss-Prot
    G3UYX5
    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_011245373.4 → XP_011243675.1  regulator of G-protein signaling 22 isoform X1

    See identical proteins and their annotated locations for XP_011243675.1

    UniProtKB/Swiss-Prot
    G3UYX5
    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_030248684.2 → XP_030104544.1  regulator of G-protein signaling 22 isoform X5

    Conserved Domains (2) summary
    cd08727
    Location:124 → 239
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:306 → 435
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. XM_011245370.4 → XP_011243672.1  regulator of G-protein signaling 22 isoform X1

    See identical proteins and their annotated locations for XP_011243672.1

    UniProtKB/Swiss-Prot
    G3UYX5
    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  6. XM_030248683.2 → XP_030104543.1  regulator of G-protein signaling 22 isoform X2

    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  7. XM_011245374.4 → XP_011243676.1  regulator of G-protein signaling 22 isoform X2

    Conserved Domains (4) summary
    cd08725
    Location:1019 → 1141
    RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:408 → 530
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  8. XM_036159533.1 → XP_036015426.1  regulator of G-protein signaling 22 isoform X3

    Conserved Domains (3) summary
    cd08726
    Location:846 → 975
    RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
    cd08727
    Location:664 → 779
    RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
    cl02565
    Location:1019 → 1116
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  9. XM_011245375.4 → XP_011243677.1  regulator of G-protein signaling 22 isoform X4

    Conserved Domains (1) summary
    cl02565
    Location:664 → 724
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3UYX5.1 GenPept UniProtKB/Swiss-Prot:G3UYX5

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