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Zfp971 zinc finger protein 971 [ Mus musculus (house mouse) ]

Gene ID: 626848, updated on 3-Apr-2024

Summary

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Official Symbol
Zfp971provided by MGI
Official Full Name
zinc finger protein 971provided by MGI
Primary source
MGI:MGI:1261426
See related
Ensembl:ENSMUSG00000074519 AllianceGenome:MGI:1261426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etohi1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF101 (zinc finger protein 101). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.2), cerebellum adult (RPKM 2.7) and 25 other tissues See more
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Genomic context

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See Zfp971 in Genome Data Viewer
Location:
2 H4; 2 99.63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177665077..177677652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178023284..178035859)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06697 Neighboring gene predicted gene 14428 Neighboring gene STARR-seq mESC enhancer starr_06698 Neighboring gene STARR-positive B cell enhancer ABC_E6035 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177757807-177758108 Neighboring gene predicted gene, 40030 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177792959-177793260 Neighboring gene STARR-seq mESC enhancer starr_06699 Neighboring gene zinc finger protein 931 Neighboring gene phosphatase and actin regulator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Rout UK, et al. Cell Calcium, 1997 Dec. PMID 9502196
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ethanol induced 1
Names
KRAB box and zinc finger, C2H2 type domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177399.1 → NP_001170870.1  ethanol induced 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK005093, BX284639
    Consensus CDS
    CCDS50834.1
    UniProtKB/TrEMBL
    A2BFG8
    Related
    ENSMUSP00000104554.3, ENSMUST00000108926.3
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:75 → 458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:385 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:398 → 422
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001177400.1 → NP_001170871.1  ethanol induced 1 isoform 2

    See identical proteins and their annotated locations for NP_001170871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the 3' exon, but has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) is C-terminal truncated, as compared to isoform 1.
    Source sequence(s)
    AK005093, U94840
    Consensus CDS
    CCDS50835.1
    UniProtKB/TrEMBL
    A2ARV8, Q3V498
    Related
    ENSMUSP00000104553.3, ENSMUST00000108925.10
    Conserved Domains (2) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    177665077..177677652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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