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BCORL1 BCL6 corepressor like 1 [ Homo sapiens (human) ]

Gene ID: 63035, updated on 5-Mar-2024

Summary

Official Symbol
BCORL1provided by HGNC
Official Full Name
BCL6 corepressor like 1provided by HGNC
Primary source
HGNC:HGNC:25657
See related
Ensembl:ENSG00000085185 MIM:300688; AllianceGenome:HGNC:25657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHUVER; BCoR-L1; CXorf10
Summary
The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in placenta (RPKM 4.2), testis (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

Location:
Xq26.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (129980313..130058071)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128299075..128376871)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129114955..129192046)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 4 pseudogene 2 Neighboring gene uncharacterized LOC105373335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20981 Neighboring gene UTP14A small subunit processome component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129086824-129087554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129093062-129093562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20985 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129117440-129117676 Neighboring gene uncharacterized LOC124905216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129159157-129159656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20988 Neighboring gene Sharpr-MPRA regulatory region 15346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20989 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene Sharpr-MPRA regulatory region 9263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20995 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129255011-129255220 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:129280263-129281462 Neighboring gene apoptosis inducing factor mitochondria associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29939

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Shukla-Vernon syndrome
MedGen: C5193146 OMIM: 301029 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11362, FLJ11632

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
BCL-6 corepressor-like protein 1
Names
BCoR-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021274.1 RefSeqGene

    Range
    27496..80390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_628

mRNA and Protein(s)

  1. NM_001184772.3NP_001171701.1  BCL-6 corepressor-like protein 1 isoform 1a

    See identical proteins and their annotated locations for NP_001171701.1

    Status: REVIEWED

    Source sequence(s)
    AL034405, AL136450, KF459400, Z82208
    Consensus CDS
    CCDS94663.1
    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001379450.1NP_001366379.1  BCL-6 corepressor-like protein 1 isoform 1a

    Status: REVIEWED

    Source sequence(s)
    AL034405, AL136450, KF459400, Z82208
    Consensus CDS
    CCDS94663.1
    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001379451.1NP_001366380.1  BCL-6 corepressor-like protein 1 isoform 1a

    Status: REVIEWED

    Source sequence(s)
    AL034405, AL136450, KF459400, Z82208
    Consensus CDS
    CCDS94663.1
    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Related
    ENSP00000437775.2, ENST00000540052.6
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_021946.5NP_068765.3  BCL-6 corepressor-like protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL034405, AL136450, KF459400, Z82208
    Consensus CDS
    CCDS14616.1
    UniProtKB/Swiss-Prot
    Q5H9F3
    Related
    ENSP00000218147.7, ENST00000218147.11
    Conserved Domains (4) summary
    cd00204
    Location:14261530
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14260
    Location:15921705
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam12796
    Location:14261517
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:14551486
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    129980313..130058071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262453.5XP_005262510.2  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005262510.2

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006724777.4XP_006724840.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006724840.1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_047442344.1XP_047298300.1  BCL-6 corepressor-like protein 1 isoform X2

  4. XM_017029721.2XP_016885210.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_047442341.1XP_047298297.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  6. XM_047442340.1XP_047298296.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  7. XM_005262456.5XP_005262513.2  BCL-6 corepressor-like protein 1 isoform X2

    Conserved Domains (5) summary
    cd00204
    Location:13601474
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14260
    Location:15361649
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam12796
    Location:13701461
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:11841297
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    sd00045
    Location:13661397
    ANK; ANK repeat [structural motif]
  8. XM_047442345.1XP_047298301.1  BCL-6 corepressor-like protein 1 isoform X2

  9. XM_006724776.4XP_006724839.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006724839.1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  10. XM_047442343.1XP_047298299.1  BCL-6 corepressor-like protein 1 isoform X2

  11. XM_047442342.1XP_047298298.1  BCL-6 corepressor-like protein 1 isoform X2

  12. XM_005262455.5XP_005262512.2  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005262512.2

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  13. XM_047442339.1XP_047298295.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  14. XM_017029722.2XP_016885211.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
    Conserved Domains (4) summary
    PHA03247
    Location:198636
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:16661779
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    sd00045
    Location:14961527
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:15001591
    Ank_2; Ankyrin repeats (3 copies)
  15. XM_047442347.1XP_047298303.1  BCL-6 corepressor-like protein 1 isoform X4

  16. XM_047442346.1XP_047298302.1  BCL-6 corepressor-like protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    128299075..128376871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327551.1XP_054183526.1  BCL-6 corepressor-like protein 1 isoform X2

  2. XM_054327544.1XP_054183519.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  3. XM_054327548.1XP_054183523.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  4. XM_054327553.1XP_054183528.1  BCL-6 corepressor-like protein 1 isoform X2

  5. XM_054327543.1XP_054183518.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  6. XM_054327545.1XP_054183520.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  7. XM_054327542.1XP_054183517.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  8. XM_054327549.1XP_054183524.1  BCL-6 corepressor-like protein 1 isoform X2

  9. XM_054327546.1XP_054183521.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  10. XM_054327552.1XP_054183527.1  BCL-6 corepressor-like protein 1 isoform X2

  11. XM_054327550.1XP_054183525.1  BCL-6 corepressor-like protein 1 isoform X2

  12. XM_054327540.1XP_054183515.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  13. XM_054327541.1XP_054183516.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  14. XM_054327547.1XP_054183522.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B5MDQ8, Q5H9F2, Q5H9F3, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
  15. XM_054327555.1XP_054183530.1  BCL-6 corepressor-like protein 1 isoform X4

  16. XM_054327554.1XP_054183529.1  BCL-6 corepressor-like protein 1 isoform X3