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UBE2O ubiquitin conjugating enzyme E2 O [ Homo sapiens (human) ]

Gene ID: 63893, updated on 5-Mar-2024

Summary

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Official Symbol
UBE2Oprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Oprovided by HGNC
Primary source
HGNC:HGNC:29554
See related
Ensembl:ENSG00000175931 MIM:617649; AllianceGenome:HGNC:29554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2-230K
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

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See UBE2O in Genome Data Viewer
Location:
17q25.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76389456..76453152, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77286031..77349733, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74385537..74449234, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74346967-74347514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74349963-74350827 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 43 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74364234-74364734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74364735-74365235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9015 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74386817-74386991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74394983-74395483 Neighboring gene sphingosine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74418617-74419118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74419119-74419618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74429943-74430443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74432809-74433310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74437133-74437650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12806 Neighboring gene ribosomal protein L7 pseudogene 49 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9016 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74449240-74449408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12808 Neighboring gene aralkylamine N-acetyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74469380-74469890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9020 Neighboring gene Sharpr-MPRA regulatory region 10531 Neighboring gene MPRA-validated peak3008 silencer Neighboring gene rhomboid 5 homolog 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74487839-74488704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74496763-74497432

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma. Lan SY, et al. Curr Med Sci, 2023 Feb. PMID 36269535
  2. UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway. Shi Z, et al. Int J Med Sci, 2021. PMID 34790050, Free PMC Article
  3. UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop. Liu X, et al. Cell Death Dis, 2020 Jan 6. PMID 31907353, Free PMC Article
  4. Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset. Ullah K, et al. FEBS J, 2019 Jun. PMID 30468556
  5. UBE2O is a quality control factor for orphans of multiprotein complexes. Yanagitani K, et al. Science, 2017 Aug 4. PMID 28774922, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease.
    Title: Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease.
  2. High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma.
    Title: High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma.
  3. Mechanism of client selection by the protein quality-control factor UBE2O.
    Title: Mechanism of client selection by the protein quality-control factor UBE2O.
  4. UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKalpha2/mTOR pathway.
    Title: UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway.
  5. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.
    Title: UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.
  6. UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance.
    Title: UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance.
  7. Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6.
    Title: Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6.
  8. UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKalpha2/mTORC1-MYC positive feedback loop.
    Title: UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
  9. Study found that UBE2O is markedly upregulated in obese subjects with type 2 diabetes.
    Title: A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity.
  10. UBE2O directly mediates the ubiquitination of many substrates, including AMPKalpha2, BAP1, MLL protein SMAD6, c-Maf, ARNTL, and free ribosomal proteins. UBE2O is frequently amplified or mutated in multiple cancers, and its high expression is associated with low survival rate of gastric, lung, breast, and prostate cancer patients. Review.
    Title: Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with ubiquitin-conjugating enzyme E2O (UBE2O) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12878, KIAA1734

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
(E3-independent) E2 ubiquitin-conjugating enzyme
Names
E2/E3 hybrid ubiquitin-protein ligase UBE2O
ubiquitin carrier protein O
ubiquitin conjugating enzyme E2O
ubiquitin-conjugating enzyme E2 of 230 kDa
ubiquitin-conjugating enzyme E2-230K
ubiquitin-protein ligase O
NP_071349.3
XP_005257624.1
XP_016880424.1
XP_024306633.1
XP_024306634.1
XP_024306635.1
XP_047292473.1
XP_047292474.1
XP_054172853.1
XP_054172854.1
XP_054172855.1
XP_054172856.1
XP_054172857.1
XP_054172858.1
XP_054172859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022066.4 → NP_071349.3  (E3-independent) E2 ubiquitin-conjugating enzyme

    See identical proteins and their annotated locations for NP_071349.3

    Status: VALIDATED

    Source sequence(s)
    AB051521, AC090699, BC025977, DA092358
    Consensus CDS
    CCDS32742.1
    UniProtKB/Swiss-Prot
    A6NDU5, Q69YP4, Q6PIZ2, Q86UA4, Q8N425, Q8TBN1, Q9BSW1, Q9C0C9, Q9H6E6, Q9H7E4, Q9H9B2
    Related
    ENSP00000323687.6, ENST00000319380.12
    Conserved Domains (1) summary
    cd00195
    Location:958 → 1108
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76389456..76453152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024935.2 → XP_016880424.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X7

  2. XM_047436518.1 → XP_047292474.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X6

  3. XM_005257567.2 → XP_005257624.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X5

    See identical proteins and their annotated locations for XP_005257624.1

    Conserved Domains (1) summary
    cd00195
    Location:959 → 1109
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. XM_047436517.1 → XP_047292473.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X4

  5. XM_024450867.2 → XP_024306635.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3

    Conserved Domains (1) summary
    cd00195
    Location:970 → 1120
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  6. XM_024450866.2 → XP_024306634.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2

    Conserved Domains (1) summary
    cd00195
    Location:994 → 1144
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  7. XM_024450865.2 → XP_024306633.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

    Conserved Domains (1) summary
    cd00195
    Location:995 → 1145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77286031..77349733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316884.1 → XP_054172859.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X7

  2. XM_054316883.1 → XP_054172858.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X6

  3. XM_054316882.1 → XP_054172857.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X5

  4. XM_054316881.1 → XP_054172856.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X4

  5. XM_054316880.1 → XP_054172855.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3

  6. XM_054316879.1 → XP_054172854.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2

  7. XM_054316878.1 → XP_054172853.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0C9.3 GenPept UniProtKB/Swiss-Prot:Q9C0C9

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