Format

Send to:

Choose Destination

Syne1 spectrin repeat containing, nuclear envelope 1 [ Mus musculus (house mouse) ]

Gene ID: 64009, updated on 23-Jun-2021

Summary

Official Symbol
Syne1provided by MGI
Official Full Name
spectrin repeat containing, nuclear envelope 1provided by MGI
Primary source
MGI:MGI:1927152
See related
Ensembl:ENSMUSG00000096054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8B; nes; CPG2; SYNE; KASH1; Myne1; enapt; myne-1; BE692247; mKIAA1756; A330049M09Rik; C130039F11Rik
Expression
Biased expression in cerebellum adult (RPKM 19.1), frontal lobe adult (RPKM 7.9) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Syne1 in Genome Data Viewer
Location:
10; 10 A1
Exon count:
152
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4970192..5501013, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5020192..5550692, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (4795849..5326349)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene estrogen receptor 1 (alpha) Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573 Neighboring gene predicted gene, 40594 Neighboring gene predicted gene, 51758 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1756, MGC62825

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytoskeleton-nuclear membrane anchor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lamin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear matrix anchoring at nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
nesprin-1
Names
KASH domain-containing protein 1
enaptin
enaptin165
myocyte nuclear envelope protein 1
nesprin 1
nuclear envelope spectrin repeat protein 1
synaptic nuclear envelope 1
synaptic nuclear envelope protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079686.1NP_001073154.1  nesprin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region found in variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (3) is shorter and has distinct N-terminus compared to isoform 4.
    Source sequence(s)
    AC156393, AC162381, AF281870, AK041626, BC041779, BC110426
    UniProtKB/Swiss-Prot
    Q6ZWR6
    UniProtKB/TrEMBL
    Q6PI72
    Conserved Domains (4) summary
    COG4942
    Location:292549
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:22162426
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:29533009
    KASH; Nuclear envelope localization domain
    cl02488
    Location:13771565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_001347711.1NP_001334640.1  nesprin-1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC156392, AC156393, AC159748, AC161829, AC162381, AC162385
  3. NM_001347732.1NP_001334661.1  nesprin-1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variants (5) differs in the 5' UTR and has multiple difference in the coding region compared variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (5) has a unique N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AC156392, AC156393, AC157020, AC159748, AC161829, AC162381, AC162385
    Consensus CDS
    CCDS87951.1
    UniProtKB/TrEMBL
    A0A1L1STC6
    Related
    ENSMUSP00000150262.2, ENSMUST00000215295.2
  4. NM_022027.2NP_071310.2  nesprin-1 isoform 2

    See identical proteins and their annotated locations for NP_071310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 4.
    Source sequence(s)
    AC156393, BC041779, BC054456
    Consensus CDS
    CCDS56679.1
    UniProtKB/TrEMBL
    Q0VGB8, Q6PI72, Q7TQH5
    Related
    ENSMUSP00000093587.4, ENSMUST00000095899.5
    Conserved Domains (2) summary
    cd00176
    Location:155365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:892948
    KASH; Nuclear envelope localization domain
  5. NM_153399.2NP_700448.2  nesprin-1 isoform 1

    See identical proteins and their annotated locations for NP_700448.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in both UTRs and has multiple differences in the coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 4.
    Source sequence(s)
    AC157020, AK039486, AK044459, AK122550
    Consensus CDS
    CCDS56680.1
    UniProtKB/TrEMBL
    Q6ZWR1, Q6ZWR5, Q80T95
    Related
    ENSMUSP00000039440.6, ENSMUST00000041639.7
    Conserved Domains (3) summary
    cd00014
    Location:28141
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00307
    Location:187285
    CH; Calponin homology (CH) domain
    cl02488
    Location:8421006
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4970192..5501013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155919.1XP_036011812.1  nesprin-1 isoform X9

    Conserved Domains (9) summary
    COG0419
    Location:37924354
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28563639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60556313
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79808190
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49445779
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87408796
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43264542
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. XM_036155938.1XP_036011831.1  nesprin-1 isoform X29

    Conserved Domains (9) summary
    COG0419
    Location:38084370
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28723655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60676324
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79918201
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49605795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87288784
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43424558
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_036155916.1XP_036011809.1  nesprin-1 isoform X5

    Conserved Domains (9) summary
    COG0419
    Location:38084370
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28723655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60716329
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79968206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49605795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87568812
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43424558
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_036155917.1XP_036011810.1  nesprin-1 isoform X6

    Conserved Domains (9) summary
    COG0419
    Location:37994361
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28633646
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60626320
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79878197
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49515786
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87478803
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43334549
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  5. XM_036155924.1XP_036011817.1  nesprin-1 isoform X16

    Conserved Domains (8) summary
    COG0419
    Location:37634325
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG4942
    Location:60266284
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79518161
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49155750
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87118767
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:42974513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_036155923.1XP_036011816.1  nesprin-1 isoform X15

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60276285
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79528162
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87128768
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_036155921.1XP_036011814.1  nesprin-1 isoform X13

    Conserved Domains (9) summary
    TIGR00618
    Location:56316278
    sbcc; exonuclease SbcC
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79568166
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87168772
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. XM_036155920.1XP_036011813.1  nesprin-1 isoform X11

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60746331
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79988208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87358791
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. XM_036155915.1XP_036011808.1  nesprin-1 isoform X4

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60746331
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79988208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87588814
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. XM_036155914.1XP_036011807.1  nesprin-1 isoform X3

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60746332
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:79998209
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87598815
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  11. XM_036155932.1XP_036011825.1  nesprin-1 isoform X23

    Conserved Domains (8) summary
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786335
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80028212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:41434439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  12. XM_036155913.1XP_036011806.1  nesprin-1 isoform X2

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786335
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80028212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87628818
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  13. XM_036155931.1XP_036011824.1  nesprin-1 isoform X22

    Conserved Domains (8) summary
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:41434439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  14. XM_036155925.1XP_036011818.1  nesprin-1 isoform X17

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:86928748
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  15. XM_036155922.1XP_036011815.1  nesprin-1 isoform X14

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87158771
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  16. XM_036155927.1XP_036011820.1  nesprin-1 isoform X19

    Conserved Domains (8) summary
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:41434439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  17. XM_036155918.1XP_036011811.1  nesprin-1 isoform X8

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87408796
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  18. XM_036155926.1XP_036011819.1  nesprin-1 isoform X18

    Conserved Domains (8) summary
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:41434439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  19. XM_036155912.1XP_036011805.1  nesprin-1 isoform X1

    Conserved Domains (9) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:80038213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:87638819
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  20. XM_036155928.1XP_036011821.1  nesprin-1 isoform X20

    Conserved Domains (8) summary
    COG1196
    Location:27473530
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:59466204
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:78718081
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48355670
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:40114307
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:86318687
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:42174433
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  21. XM_036155929.1XP_036011822.1  nesprin-1 isoform X21

    Conserved Domains (8) summary
    COG1196
    Location:27313514
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:59306188
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:78558065
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48195654
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:39954291
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:86158671
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:42014417
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  22. XM_011243086.3XP_011241388.1  nesprin-1 isoform X7

    Conserved Domains (10) summary
    TIGR03785
    Location:11721244
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:37994361
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28633646
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60626320
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:79878197
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49515786
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:59226099
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:43334549
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:87478803
    KASH; Nuclear envelope localization domain
  23. XM_030245204.2XP_030101064.1  nesprin-1 isoform X12

    Conserved Domains (10) summary
    TIGR03785
    Location:11561228
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:37834345
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28473630
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60466304
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:79718181
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49355770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:59066083
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:43174533
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:87318787
    KASH; Nuclear envelope localization domain
  24. XM_036155930.1XP_036011823.1  nesprin-1 isoform X21

    Conserved Domains (8) summary
    COG1196
    Location:27313514
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:59306188
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:78558065
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48195654
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:39954291
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:86158671
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:42014417
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  25. XM_017314044.3XP_017169533.1  nesprin-1 isoform X10

    Conserved Domains (10) summary
    TIGR03785
    Location:11631235
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:37904352
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28543637
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60536311
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15274
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:79788188
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49425777
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:59136090
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:43244540
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:87388794
    KASH; Nuclear envelope localization domain
  26. XM_036155933.1XP_036011826.1  nesprin-1 isoform X24

    Conserved Domains (7) summary
    COG1196
    Location:23973180
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:55965854
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:75217731
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:44855320
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:36613957
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:82818337
    KASH; Nuclear envelope localization domain
    cl02488
    Location:38674083
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  27. XM_036155934.1XP_036011827.1  nesprin-1 isoform X25

    Conserved Domains (7) summary
    COG1196
    Location:23733156
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:55725830
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:74977707
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:44615296
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:36373933
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:82578313
    KASH; Nuclear envelope localization domain
    cl02488
    Location:38434059
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  28. XM_036155937.1XP_036011830.1  nesprin-1 isoform X28

    Conserved Domains (2) summary
    cd00176
    Location:155365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:915971
    KASH; Nuclear envelope localization domain
  29. XM_036155935.1XP_036011828.1  nesprin-1 isoform X26

    Conserved Domains (7) summary
    COG1196
    Location:28793662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:60786266
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:38214011
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49675802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  30. XM_036155936.1XP_036011829.1  nesprin-1 isoform X27

    Conserved Domains (7) summary
    COG0419
    Location:38154377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:28793651
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:38214036
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:11672008
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21241
    Location:24143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:43494565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Support Center