Guca2b guanylate cyclase activator 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Guca2bprovided by RGD
Official Full Name: guanylate cyclase activator 2Bprovided by RGD
Primary source: RGD:620044
See related: Ensembl:ENSRNOG00000008979 AllianceGenome:RGD:620044
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanylate cyclase activator activity. Involved in cGMP-mediated signaling. Predicted to be located in photoreceptor outer segment. Orthologous to human GUCA2B (guanylate cyclase activator 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 39.8), Thymus (RPKM 25.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (138532160..138534210, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (133246891..133248941, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (138695591..138697641, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines.
Title: Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
our data suggest that the inhibitory effect of UGN on NHE3 transport activity in proximal tubule is mediated by activation of both cGMP/PKG and cAMP/PKA signaling pathways
Title: Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule.
these studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat.
Title: The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
To respond to proUGn released from the gut, any target organ must use a local mechanism for production of active peptide.
Title: Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules.
Uroguanylin is delivered to the kidney as an unprocessed propeptide.
Title: Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide.
atrial natriuretic peptide, urodilatin, guanylin and uroguanylin interact in rat kidney
Title: Interaction of atrial natriuretic peptide, urodilatin, guanylin and uroguanylin in the isolated perfused rat kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within body fluid secretion	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylate cyclase activator 2B

Names: guanylate cyclase activator 2b (retina); uroguanylin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.