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Scn7a sodium voltage-gated channel alpha subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64155, updated on 28-Jun-2021

Summary

Official Symbol
Scn7aprovided by RGD
Official Full Name
sodium voltage-gated channel alpha subunit 7provided by RGD
Primary source
RGD:61922
See related
Ensembl:ENSRNOG00000029342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Na-G; Scn6a
Summary
glial Na-channel alpha subunit [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 437.9), Heart (RPKM 196.9) and 4 other tissues See more
Orthologs
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Genomic context

See Scn7a in Genome Data Viewer
Location:
3q21
Exon count:
26
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (51335841..51438308, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (52775779..52877365, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350387 Neighboring gene sodium voltage-gated channel alpha subunit 9 Neighboring gene histone deacetylase 1-like Neighboring gene similar to 40S ribosomal protein S3 Neighboring gene 60S ribosomal protein L9-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium channel protein type 7 subunit alpha
Names
sodium channel voltage-gated type VI alpha polypeptide
sodium channel, voltage-gated, type 6, alpha polypeptide
sodium channel, voltage-gated, type VII, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388508.1NP_001375437.1  sodium channel protein type 7 subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000115
    Conserved Domains (3) summary
    cd13433
    Location:11941245
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:9321203
    Ion_trans; Ion transport protein
    pfam06512
    Location:742926
    Na_trans_assoc; Sodium ion transport-associated

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    51335841..51438308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105781.1XP_038961709.1  sodium channel protein type 7 subunit alpha isoform X3

    Conserved Domains (3) summary
    cd13433
    Location:11581209
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:504738
    Ion_trans; Ion transport protein
    pfam06512
    Location:742926
    Na_trans_assoc; Sodium ion transport-associated
  2. XM_039105780.1XP_038961708.1  sodium channel protein type 7 subunit alpha isoform X2

    Conserved Domains (3) summary
    cd13433
    Location:11941244
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:9321199
    Ion_trans; Ion transport protein
    pfam06512
    Location:742926
    Na_trans_assoc; Sodium ion transport-associated
  3. XM_039105778.1XP_038961706.1  sodium channel protein type 7 subunit alpha isoform X1

    Conserved Domains (3) summary
    cd13433
    Location:11941245
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:9321203
    Ion_trans; Ion transport protein
    pfam06512
    Location:742926
    Na_trans_assoc; Sodium ion transport-associated
  4. XM_039105779.1XP_038961707.1  sodium channel protein type 7 subunit alpha isoform X1

    Conserved Domains (3) summary
    cd13433
    Location:11941245
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:9321203
    Ion_trans; Ion transport protein
    pfam06512
    Location:742926
    Na_trans_assoc; Sodium ion transport-associated

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031686.1: Suppressed sequence

    Description
    NM_031686.1: This RefSeq was removed because there is insufficient support for the protein.
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