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En engrailed [ Tribolium castaneum (red flour beetle) ]

Gene ID: 641551, updated on 15-Apr-2024

Summary

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Gene symbol
En
Gene description
engrailed
Primary source
BEETLEBASE:TC009896
Locus tag
TcasGA2_TC009896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Tribolium castaneum
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_04 current icTriCast1.1 (GCF_031307605.1) 3 NC_087396.1 (12117873..12149805)
103 previous assembly Tcas5.2 (GCF_000002335.3) Linkage Group LG7 NC_007422.5 (12572530..12609251, complement)

Chromosome 3 - NC_087396.1Genomic Context describing neighboring genes Neighboring gene G patch domain-containing protein 4 Neighboring gene beta-1,3-galactosyltransferase 1 Neighboring gene uncharacterized LOC661554 Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene engrailed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic control of early embryogenesis in the red flour beetle, Tribolium castaneum. Brown SJ, et al. Am Zool, 1994. PMID 11540629
  2. Genetic regulation of engrailed and wingless in Tribolium segmentation and the evolution of pair-rule segmentation. Choe CP, et al. Dev Biol, 2009 Jan 15. PMID 19028487
  3. Altered patterns of gene expression in Tribolium segmentation mutants. Sulston IA, et al. Dev Genet, 1998. PMID 9706694
  4. Embryonic expression of the single Tribolium engrailed homolog. Brown SJ, et al. Dev Genet, 1994. PMID 8187351
  5. Hedgehog signaling pathway function conserved in Tribolium segmentation. Farzana L, et al. Dev Genes Evol, 2008 Apr. PMID 18392879, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although orthologs of some Drosophila pair-rule genes are not required for proper segmentation in Tribolium, segmental expression of Tc-en and Tc-wg is conserved
    Title: Genetic regulation of engrailed and wingless in Tribolium segmentation and the evolution of pair-rule segmentation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
engrailed
Names
AUGUSTUS-3.0.2_09896
GLEAN_09896
Segmentation polarity homeobox protein engrailed-like Protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039422.2 → NP_001034511.2  engrailed

    See identical proteins and their annotated locations for NP_001034511.2

    Status: VALIDATED

    Source sequence(s)
    AAJJ02002702, AAJJ02002703
    UniProtKB/TrEMBL
    Q26371
    Conserved Domains (2) summary
    pfam00046
    Location:231 → 284
    Homeobox; Homeobox domain
    pfam10525
    Location:286 → 315
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference icTriCast1.1 Primary Assembly

Genomic

  1. NC_087396.1 Reference icTriCast1.1 Primary Assembly

    Range
    12117873..12149805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015981557.2 → XP_015837043.1  engrailed isoform X1

    UniProtKB/TrEMBL
    Q26371
    Conserved Domains (2) summary
    pfam00046
    Location:257 → 310
    Homeobox; Homeobox domain
    pfam10525
    Location:312 → 341
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

  2. XM_064355274.1 → XP_064211344.1  engrailed isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials