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St7 suppression of tumorigenicity 7 [ Mus musculus (house mouse) ]

Gene ID: 64213, updated on 16-Oct-2021

Summary

Official Symbol
St7provided by MGI
Official Full Name
suppression of tumorigenicity 7provided by MGI
Primary source
MGI:MGI:1927450
See related
Ensembl:ENSMUSG00000029534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HELG; RAY1; SEN4; TSG7; Fam4a2; 9430001H04Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.7) and 28 other tissues See more
Orthologs
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Genomic context

See St7 in Genome Data Viewer
Location:
6; 6 A2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17693579..17943022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17693901..17943023)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (17699216..17893022)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53318 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2 Neighboring gene four and a half LIM domains 3 pseudogene Neighboring gene metal response element binding transcription factor 2 pseudogene Neighboring gene predicted gene, 52895 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC118540

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
suppressor of tumorigenicity 7 protein
Names
4low density lipoprotein-related protein 12
family with sequence similarity 4, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083315.2NP_001076784.1  suppressor of tumorigenicity 7 protein isoform 2

    See identical proteins and their annotated locations for NP_001076784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC068561, AK079107, AK132103
    Consensus CDS
    CCDS39431.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000111077.4, ENSMUST00000115417.4
    Conserved Domains (1) summary
    cd11557
    Location:11475
    ST7; Suppression of tumorigenicity 7
  2. NM_001289624.1NP_001276553.1  suppressor of tumorigenicity 7 protein isoform 3

    See identical proteins and their annotated locations for NP_001276553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71728.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000080341.7, ENSMUST00000081635.13
    Conserved Domains (1) summary
    pfam04184
    Location:19576
    ST7; ST7 protein
  3. NM_001289625.1NP_001276554.1  suppressor of tumorigenicity 7 protein isoform 4

    See identical proteins and their annotated locations for NP_001276554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an alternate in-frame splice site, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS80490.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000111079.2, ENSMUST00000115419.8
    Conserved Domains (1) summary
    pfam04184
    Location:19571
    ST7; ST7 protein
  4. NM_001289626.1NP_001276555.1  suppressor of tumorigenicity 7 protein isoform 5

    See identical proteins and their annotated locations for NP_001276555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71729.1
    UniProtKB/TrEMBL
    Q99M95
    Related
    ENSMUSP00000062886.6, ENSMUST00000052113.12
    Conserved Domains (1) summary
    pfam04184
    Location:19553
    ST7; ST7 protein
  5. NM_001289627.1NP_001276556.1  suppressor of tumorigenicity 7 protein isoform 6

    See identical proteins and their annotated locations for NP_001276556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71730.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000076334.3, ENSMUST00000077080.9
    Conserved Domains (1) summary
    pfam04184
    Location:4530
    ST7; ST7 protein
  6. NM_001289629.1NP_001276558.1  suppressor of tumorigenicity 7 protein isoform 7

    See identical proteins and their annotated locations for NP_001276558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068561, AC153836
    Consensus CDS
    CCDS71731.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000000674.7, ENSMUST00000000674.13
    Conserved Domains (1) summary
    pfam04184
    Location:4507
    ST7; ST7 protein
  7. NM_022332.3NP_071727.2  suppressor of tumorigenicity 7 protein isoform 1

    See identical proteins and their annotated locations for NP_071727.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK079107, BC108418, BY479263
    Consensus CDS
    CCDS19927.1
    UniProtKB/Swiss-Prot
    Q99M96
    Related
    ENSMUSP00000057326.8, ENSMUST00000053148.14
    Conserved Domains (1) summary
    cd11557
    Location:11498
    ST7; Suppression of tumorigenicity 7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    17693579..17943022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241076.4XP_011239378.1  suppressor of tumorigenicity 7 protein isoform X1

    Conserved Domains (1) summary
    cd11557
    Location:1377
    ST7; Suppression of tumorigenicity 7

RNA

  1. XR_004933617.1 RNA Sequence

  2. XR_868763.4 RNA Sequence

  3. XR_868764.4 RNA Sequence

  4. XR_003956242.2 RNA Sequence

  5. XR_377290.5 RNA Sequence

  6. XR_003956244.2 RNA Sequence

  7. XR_003956243.2 RNA Sequence

  8. XR_377291.5 RNA Sequence

  9. XR_003956245.2 RNA Sequence

  10. XR_003956246.2 RNA Sequence

  11. XR_003956247.2 RNA Sequence

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