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IQANK1 IQ motif and ankyrin repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 642574, updated on 5-Mar-2024

Summary

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Official Symbol
IQANK1provided by HGNC
Official Full Name
IQ motif and ankyrin repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:49576
See related
Ensembl:ENSG00000203499 MIM:618942; AllianceGenome:HGNC:49576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACClnc; FAM83HAS1; FAM83H-AS1; onco-lncRNA-3
Summary
Predicted to be involved in regulation of barbed-end actin filament capping. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143734139..143790645)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144890576..144947196)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144816309..144872815)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144805293-144805794 Neighboring gene mitogen-activated protein kinase 15 Neighboring gene Sharpr-MPRA regulatory region 4007 Neighboring gene family with sequence similarity 83 member H Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144819935-144820800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144822529-144823392 Neighboring gene microRNA 4664 Neighboring gene SREBF pathway regulator in golgi 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144852281-144852954 Neighboring gene scribble planar cell polarity protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144896321-144896985 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144897270-144897902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144897903-144898535 Neighboring gene microRNA 937 Neighboring gene poly(U) binding splicing factor 60 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:144911577-144912776 Neighboring gene uncharacterized LOC107986985

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma. Wang S, et al. Clin Transl Med, 2021 Feb. PMID 33634993, Free PMC Article
  2. Long Noncoding RNA FAM83H-AS1 Modulates SpA-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells. Wu H, et al. Mol Cell Biol, 2020 Feb 12. PMID 31871129, Free PMC Article
  3. Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/β-catenin pathway. Ma YK, et al. Eur Rev Med Pharmacol Sci, 2019 Sep. PMID 31599410
  4. FAM83H-AS1 is upregulated and predicts poor prognosis in colon cancer. Yang L, et al. Biomed Pharmacother, 2019 Oct. PMID 31545230
  5. Clinical significance of lncRNA FAM83H-AS1 in ovarian cancer. Gong YB, et al. Eur Rev Med Pharmacol Sci, 2019 Jun. PMID 31210291

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma.
    Title: FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma.
  2. Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/beta-catenin pathway.
    Title: Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/β-catenin pathway.
  3. Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells.
    Title: Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells.
  4. Clinical significance of lncRNA FAM83H-AS1 in ovarian cancer.
    Title: Clinical significance of lncRNA FAM83H-AS1 in ovarian cancer.
  5. FAM83H-AS1 role in the osteogenic differentiation of the bone mesenchymal stem cells.FAM83H-AS1 negatively regulated microRNA 541-3p and WNT3A.
    Title: Long Noncoding RNA FAM83H-AS1 Modulates SpA-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells.
  6. dysregulated expression of FAM83H-AS1 played a crucial role in progression of intervertebral disc degeneration.
    Title: LncRNA FAM83H-AS1 induces nucleus pulposus cell growth via targeting the Notch signaling pathway.
  7. The aim was to analyze the expression pattern and clinical significance of FAM83H-AS1 and further analyse its prognostic value in colon cancer.
    Title: FAM83H-AS1 is upregulated and predicts poor prognosis in colon cancer.
  8. Study validated the role of 2 uncharacterized lncRNAs, onco-lncRNA-3 and onco-lncRNA-12, and a previously reported lncRNA, CCAT1, in S-phase cell cycle across cancer types.
    Title: Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function.
  9. FAM83H-AS1 is involved in the progression of bladder cancer and serves as a prognostic biomarker and potential therapeutic target for patients with bladder cancer.
    Title: FAM83H-AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer.
  10. Loss-of-function assays demonstrated that silenced FAM83H-AS1 obviously suppressed cell proliferation via regulating the cell-cycle distribution and cell apoptosis rate, and mechanistic experiments revealed that FAM83H-AS1 could epidemically silence CDKN1A expression through recruiting EZH2 to the promoter of CDKN1A, thereby influencing the cell cycle and proliferation.
    Title: Long noncoding RNA FAM83H-AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21).
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ33892, FLJ42085, FLJ43864

General protein information

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Preferred Names
IQ motif and ankyrin repeat domain-containing protein 1
Names
Chemoresistance Associated CRC lncRNA
FAM83H antisense RNA 1 (head to head)
IQ motif and ankyrin repeat domain-containing protein LOC642574
putative IQ motif and ankyrin repeat domain-containing protein LOC642574

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381874.1 → NP_001368803.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC105219
    Consensus CDS
    CCDS94353.1
    UniProtKB/Swiss-Prot
    A0A1B0GTG1, A8MXQ7
    Related
    ENSP00000489685.1, ENST00000527139.7
    Conserved Domains (3) summary
    PTZ00322
    Location:196 → 265
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:191 → 222
    ANK; ANK repeat [structural motif]
    pfam12781
    Location:430 → 536
    AAA_9; ATP-binding dynein motor region D5

  2. NM_001381875.1 → NP_001368804.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC105219
    Consensus CDS
    CCDS94352.1
    UniProtKB/TrEMBL
    A0A1B0GUK7
    Related
    ENSP00000490151.1, ENST00000533004.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143734139..143790645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422100.1 → XP_047278056.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X2

  2. XM_047422102.1 → XP_047278058.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

  3. XM_047422099.1 → XP_047278055.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X1

  4. XM_047422101.1 → XP_047278057.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X3

  5. XM_017014127.2 → XP_016869616.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    211186..267750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328773.1 → XP_054184748.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X2

  2. XM_054328775.1 → XP_054184750.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

  3. XM_054328772.1 → XP_054184747.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X1

  4. XM_054328774.1 → XP_054184749.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X3

  5. XM_054328776.1 → XP_054184751.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144890576..144947196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361004.1 → XP_054216979.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X2

  2. XM_054361006.1 → XP_054216981.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

  3. XM_054361003.1 → XP_054216978.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X1

  4. XM_054361005.1 → XP_054216980.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X3

  5. XM_054361002.1 → XP_054216977.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MXQ7.3 GenPept UniProtKB/Swiss-Prot:A8MXQ7

Gene LinkOut

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