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NPIPA3 nuclear pore complex interacting protein family member A3 [ Homo sapiens (human) ]

Gene ID: 642778, updated on 3-Apr-2024

Summary

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Official Symbol
NPIPA3provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member A3provided by HGNC
Primary source
HGNC:HGNC:41978
See related
Ensembl:ENSG00000224712 AllianceGenome:HGNC:41978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 19.5), testis (RPKM 14.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p13.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14703411..14726342)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14797268..14820199)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene bifunctional apoptosis regulator Neighboring gene RNA, U7 small nuclear 125 pseudogene Neighboring gene phospholipase A2 group X Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14781374-14781874 Neighboring gene group 10 secretory phospholipase A2 Neighboring gene nuclear pore complex interacting protein family member A2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14860458-14860958 Neighboring gene phospholipase A2 group XE, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. Hornan DM, et al. Invest Ophthalmol Vis Sci, 2007 Dec. PMID 18055785
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277323.2 → NP_001264252.1  nuclear pore complex-interacting protein family member A3 isoform 2

    See identical proteins and their annotated locations for NP_001264252.1

    Status: VALIDATED

    Source sequence(s)
    AC009167, AC136443
    Consensus CDS
    CCDS59262.1
    UniProtKB/Swiss-Prot
    F8WFD2
    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (1) summary
    pfam06409
    Location:22 → 287
    NPIP; Nuclear pore complex interacting protein (NPIP)

  2. NM_001395487.1 → NP_001382416.1  nuclear pore complex-interacting protein family member A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009167, AC136443
    Consensus CDS
    CCDS92114.1
    UniProtKB/TrEMBL
    A0A067ZUL9, E9PNV8
    Related
    ENSP00000437133.1, ENST00000531598.7
    Conserved Domains (2) summary
    pfam06409
    Location:46 → 307
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    14703411..14726342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522576.3 → XP_011520878.2  nuclear pore complex-interacting protein family member A3 isoform X1

    UniProtKB/TrEMBL
    A0A067ZUL9

  2. XM_011522583.4 → XP_011520885.1  nuclear pore complex-interacting protein family member A3 isoform X6

    See identical proteins and their annotated locations for XP_011520885.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. XM_011522584.3 → XP_011520886.1  nuclear pore complex-interacting protein family member A3 isoform X7

    See identical proteins and their annotated locations for XP_011520886.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 266
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  4. XM_047434470.1 → XP_047290426.1  nuclear pore complex-interacting protein family member A3 isoform X6

  5. XM_011522581.2 → XP_011520883.1  nuclear pore complex-interacting protein family member A3 isoform X6

    See identical proteins and their annotated locations for XP_011520883.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  6. XM_047434468.1 → XP_047290424.1  nuclear pore complex-interacting protein family member A3 isoform X4

    UniProtKB/Swiss-Prot
    F8WFD2
    Related
    ENSP00000448841.1, ENST00000552140.6

  7. XM_005255485.4 → XP_005255542.1  nuclear pore complex-interacting protein family member A3 isoform X9

    See identical proteins and their annotated locations for XP_005255542.1

    UniProtKB/TrEMBL
    A0A067ZVG2, A0A067ZWN8, O15103
    Conserved Domains (1) summary
    pfam06409
    Location:22 → 214
    NPIP; Nuclear pore complex interacting protein (NPIP)

  8. XM_047434469.1 → XP_047290425.1  nuclear pore complex-interacting protein family member A3 isoform X5

  9. XM_011522578.3 → XP_011520880.2  nuclear pore complex-interacting protein family member A3 isoform X2

    UniProtKB/TrEMBL
    A0A067ZUL9

  10. XM_011522580.3 → XP_011520882.2  nuclear pore complex-interacting protein family member A3 isoform X3

    UniProtKB/TrEMBL
    A0A067ZUL9

  11. XM_011522585.1 → XP_011520887.1  nuclear pore complex-interacting protein family member A3 isoform X8

    See identical proteins and their annotated locations for XP_011520887.1

    UniProtKB/TrEMBL
    H0YED6
    Conserved Domains (1) summary
    pfam06409
    Location:26 → 245
    NPIP; Nuclear pore complex interacting protein (NPIP)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    276273..299205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329128.1 → XP_054185103.1  nuclear pore complex-interacting protein family member A3 isoform X10

    UniProtKB/Swiss-Prot
    E9PIF3

  2. XM_054329127.1 → XP_054185102.1  nuclear pore complex-interacting protein family member A3 isoform X10

    UniProtKB/Swiss-Prot
    E9PIF3

  3. XM_054329125.1 → XP_054185100.1  nuclear pore complex-interacting protein family member A3 isoform X1

  4. XM_054329123.1 → XP_054185098.1  nuclear pore complex-interacting protein family member A3 isoform X1

  5. XM_054329134.1 → XP_054185109.1  nuclear pore complex-interacting protein family member A3 isoform X6

  6. XM_054329135.1 → XP_054185110.1  nuclear pore complex-interacting protein family member A3 isoform X7

  7. XM_054329133.1 → XP_054185108.1  nuclear pore complex-interacting protein family member A3 isoform X6

  8. XM_054329132.1 → XP_054185107.1  nuclear pore complex-interacting protein family member A3 isoform X6

  9. XM_054329124.1 → XP_054185099.1  nuclear pore complex-interacting protein family member A3 isoform X1

  10. XM_054329130.1 → XP_054185105.1  nuclear pore complex-interacting protein family member A3 isoform X4

    UniProtKB/TrEMBL
    A0A0B4J2F6

  11. XM_054329137.1 → XP_054185112.1  nuclear pore complex-interacting protein family member A3 isoform X9

    UniProtKB/TrEMBL
    O15103

  12. XM_054329126.1 → XP_054185101.1  nuclear pore complex-interacting protein family member A3 isoform X2

  13. XM_054329131.1 → XP_054185106.1  nuclear pore complex-interacting protein family member A3 isoform X5

  14. XM_054329129.1 → XP_054185104.1  nuclear pore complex-interacting protein family member A3 isoform X3

  15. XM_054329136.1 → XP_054185111.1  nuclear pore complex-interacting protein family member A3 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8WFD2.1 GenPept UniProtKB/Swiss-Prot:F8WFD2

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