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SRSF5 serine and arginine rich splicing factor 5 [ Homo sapiens (human) ]

Gene ID: 6430, updated on 7-Apr-2024

Summary

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Official Symbol
SRSF5provided by HGNC
Official Full Name
serine and arginine rich splicing factor 5provided by HGNC
Primary source
HGNC:HGNC:10787
See related
Ensembl:ENSG00000100650 MIM:600914; AllianceGenome:HGNC:10787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRS; SFRS5; SRP40
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 175.0), skin (RPKM 153.9) and 25 other tissues See more
Orthologs
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Genomic context

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See SRSF5 in Genome Data Viewer
Location:
14q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69767142..69772005)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63934566..63979677)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70233859..70238722)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 177 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:70061623-70061793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70088656-70089156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8641 Neighboring gene sushi domain containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70104475-70104987 Neighboring gene Sharpr-MPRA regulatory region 10837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70124416-70125196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8644 Neighboring gene Sharpr-MPRA regulatory region 2331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8646 Neighboring gene Sharpr-MPRA regulatory region 930 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:70207027-70208226 Neighboring gene uncharacterized LOC100289511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70233975-70234739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8649 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:70237232-70238431 Neighboring gene solute carrier family 10 member 1 Neighboring gene Sharpr-MPRA regulatory region 10266 Neighboring gene small nucleolar RNA SNORA11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. Chen Y, et al. Nat Commun, 2018 Jun 25. PMID 29942010, Free PMC Article
  2. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection. Luo Z, et al. PLoS Pathog, 2017 Aug. PMID 28854257, Free PMC Article
  3. SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer. Kim HR, et al. Lung Cancer, 2016 Sep. PMID 27565915
  4. Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients. Vautrot V, et al. Hum Mutat, 2016 Mar. PMID 26670336
  5. Regulation of alternative splicing within the supraspliceosome. Sebbag-Sznajder N, et al. J Struct Biol, 2012 Jan. PMID 22100336, Free PMC Article

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
    Title: CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
  2. Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
    Title: Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
  3. Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
    Title: Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
  4. In this study, we uncover an alternative role for the ESCRT-0 component hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) in promoting the constitutive recycling of transmembrane proteins. We find that endosomal localization of the actin nucleating factor Wiscott-Aldrich syndrome protein and SCAR homologue (WASH) requires HRS, which occupies adjacent endosomal subdomains
    Title: HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.
  5. Cold induction of serine and arginine rich splicing factor 5 (SRSF5) is independent of cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3).
    Title: TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3.
  6. Study found that SRSF5 is a novel target of SRSF3. SRSF5 is overexpressed in oral squamous cell carcinoma (OSCC) and functions as an oncogene. Its downregulation in OSCC cell lines slows cell growth, cycle progression, and tumor growth. The expression of SRSF5 seems to controlled by an autoregulation mechanism.
    Title: SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma.
  7. upon glucose intake, the splicing factor SRSF5 is specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production.
    Title: Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
  8. we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3.
    Title: ErbB3 interacts with Hrs and is sorted to lysosomes for degradation.
  9. the up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover, we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells.
    Title: SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer.
  10. this study demonstrates that HRS acts as a key component of TLR7 signaling to orchestrate immune and inflammatory responses during EV71 infection
    Title: HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
Nef nef The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
Pr55(Gag) gag Human CRM1 and SRp40 increase the amount of unspliced HIV-1 RNA and have a more-than-additive effect on HIV-1 titers in mouse cells PubMed
gag SR proteins, particularly SRp40 and SRp55, increase HIV-1 Gag translation from unspliced viral RNA. The second RNA recognition motif and the arginine-serine (RS) domain are determinants of SR protein activity PubMed
Rev rev SF2/ASF and SRp40 interact with a purine-rich motif within the HIV-1 exon 5, and this interaction activates splicing at an upstream 3' splice site and binding of the 5' splice site to U1 snRNP, which are required for splicing of HIV-1 rev and nef mRNAs PubMed
Vpu vpu The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
capsid gag Human CRM1 and SRp40 have a more-than-additive effect on HIV-1 CA production in mouse cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA splice site recognition TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 5
Names
SR splicing factor 5
delayed-early protein HRS
pre-mRNA-splicing factor SRP40
splicing factor, arginine/serine-rich 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039465.2 → NP_001034554.1  serine/arginine-rich splicing factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001034554.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA640719, BC018823, BU928782
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    O14797, Q13243, Q16662, Q49AD6, Q6FGE0
    Related
    ENSP00000377892.2, ENST00000394366.6
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  2. NM_001320214.2 → NP_001307143.1  serine/arginine-rich splicing factor 5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157789, BC040209, DC307911
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    O14797, Q13243, Q16662, Q49AD6, Q6FGE0
    Related
    ENSP00000451088.1, ENST00000557154.6
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  3. NM_001411040.1 → NP_001397969.1  serine/arginine-rich splicing factor 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL157789
    Consensus CDS
    CCDS91892.1
    UniProtKB/TrEMBL
    B4DUA4

  4. NM_006925.5 → NP_008856.2  serine/arginine-rich splicing factor 5 isoform 1

    See identical proteins and their annotated locations for NP_008856.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157789, BX407495, DR761538
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    O14797, Q13243, Q16662, Q49AD6, Q6FGE0
    Related
    ENSP00000451391.1, ENST00000553635.5
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    69767142..69772005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021593.3 → XP_016877082.1  serine/arginine-rich splicing factor 5 isoform X1

    Related
    ENST00000556587.5
    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  2. XM_005267999.3 → XP_005268056.1  serine/arginine-rich splicing factor 5 isoform X1

    See identical proteins and their annotated locations for XP_005268056.1

    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  3. XM_011537077.4 → XP_011535379.1  serine/arginine-rich splicing factor 5 isoform X2

    See identical proteins and their annotated locations for XP_011535379.1

    Conserved Domains (2) summary
    cd12337
    Location:5 → 66
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:75 → 145
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

  4. XM_005268000.3 → XP_005268057.1  serine/arginine-rich splicing factor 5 isoform X1

    See identical proteins and their annotated locations for XP_005268057.1

    Conserved Domains (2) summary
    cd12595
    Location:5 → 74
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99 → 179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

  5. XM_047431683.1 → XP_047287639.1  serine/arginine-rich splicing factor 5 isoform X2

  6. XM_047431684.1 → XP_047287640.1  serine/arginine-rich splicing factor 5 isoform X4

    UniProtKB/TrEMBL
    B4DUA4
    Related
    ENSP00000452449.1, ENST00000553369.5

  7. XM_047431685.1 → XP_047287641.1  serine/arginine-rich splicing factor 5 isoform X4

    UniProtKB/TrEMBL
    B4DUA4
    Related
    ENSP00000450918.1, ENST00000554021.1

  8. XM_017021594.3 → XP_016877083.1  serine/arginine-rich splicing factor 5 isoform X3

    UniProtKB/TrEMBL
    Q86U32
    Conserved Domains (1) summary
    cl17169
    Location:1 → 51
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    63934566..63979677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376577.1 → XP_054232552.1  serine/arginine-rich splicing factor 5 isoform X5

    UniProtKB/Swiss-Prot
    O14797, Q13243, Q16662, Q49AD6, Q6FGE0

  2. XM_054376578.1 → XP_054232553.1  serine/arginine-rich splicing factor 5 isoform X5

    UniProtKB/Swiss-Prot
    O14797, Q13243, Q16662, Q49AD6, Q6FGE0

  3. XM_054376581.1 → XP_054232556.1  serine/arginine-rich splicing factor 5 isoform X1

  4. XM_054376583.1 → XP_054232558.1  serine/arginine-rich splicing factor 5 isoform X2

  5. XM_054376586.1 → XP_054232561.1  serine/arginine-rich splicing factor 5 isoform X4

    UniProtKB/TrEMBL
    B4DUA4

  6. XM_054376579.1 → XP_054232554.1  serine/arginine-rich splicing factor 5 isoform X1

  7. XM_054376582.1 → XP_054232557.1  serine/arginine-rich splicing factor 5 isoform X2

  8. XM_054376585.1 → XP_054232560.1  serine/arginine-rich splicing factor 5 isoform X4

    UniProtKB/TrEMBL
    B4DUA4

  9. XM_054376580.1 → XP_054232555.1  serine/arginine-rich splicing factor 5 isoform X1

  10. XM_054376584.1 → XP_054232559.1  serine/arginine-rich splicing factor 5 isoform X3

    UniProtKB/TrEMBL
    Q86U32
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13243.1 GenPept UniProtKB/Swiss-Prot:Q13243

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