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MAP1LC3B2 microtubule associated protein 1 light chain 3 beta 2 [ Homo sapiens (human) ]

Gene ID: 643246, updated on 11-Jun-2021

Summary

Official Symbol
MAP1LC3B2provided by HGNC
Official Full Name
microtubule associated protein 1 light chain 3 beta 2provided by HGNC
Primary source
HGNC:HGNC:34390
See related
Ensembl:ENSG00000258102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG8G
Expression
Ubiquitous expression in bone marrow (RPKM 28.8), brain (RPKM 18.9) and 25 other tissues See more
Orthologs
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Genomic context

See MAP1LC3B2 in Genome Data Viewer
Location:
12q24.22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (116559381..116576606)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (116997186..117014411)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2457 Neighboring gene long intergenic non-protein coding RNA 173 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene ribosomal protein L21 pseudogene 105 Neighboring gene ring finger protein, transmembrane 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Treatment of macrophages (24-72 hours) with purified HIV-1 increases MAP1LC3B2 (LC3B-II) in a dose-dependent manner in the absence of cytotoxic effects (indicates induction and flux of autophagy) with observed increase lost at day 7 post-infection onward PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag HIV-1 CA colocalizes with MAP1LC3B2 and MAP1LC3B2/SQSTM1 as demonstrated via fluorescence microscopy PubMed
matrix gag HIV-1 colocalizes with MAP1LC3B2 and MAP1LC3B2/SQSTM1 as demonstrated via fluorescence microscopy PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated proteins 1A/1B light chain 3 beta 2
Names
Microtubule-associated proteins 1A/1B light chain 3B-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085481.3NP_001078950.1  microtubule-associated proteins 1A/1B light chain 3 beta 2

    See identical proteins and their annotated locations for NP_001078950.1

    Status: VALIDATED

    Source sequence(s)
    AC125603, AI540365, AI719464, DN994744
    Consensus CDS
    CCDS41841.1
    UniProtKB/Swiss-Prot
    A6NCE7
    Related
    ENSP00000450524.1, ENST00000556529.4
    Conserved Domains (1) summary
    cd01611
    Location:7120
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    116559381..116576606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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