Kcna6 potassium voltage-gated channel subfamily A member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcna6provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A member 6provided by RGD
Primary source: RGD:62083
See related: Ensembl:ENSRNOG00000052486 AllianceGenome:RGD:62083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv1.6
Summary: Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 100.8), Lung (RPKM 7.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161229103..161262352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (159542941..159576189, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (159253934..159287193, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.
Title: The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.
down-regulation of the Kv1.6 protein and mRNA may be associated with maturation of excitable properties of primary vestibular neurons
Title: Developmental changes in the expression of Κv1 potassium channels in rat vestibular ganglion cells.
N-type inactivation prevention (NIP) domain function was shown to require positioning of Kv1.6 adjacent to the Kv1.4 subunit.
Title: Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels.
Consistent with these findings, strong immunoreactivities for Kv1.1 and Kv1.6, among 4-AP-sensitive and low-voltage-activated Kv1 family examined, were detected in the soma but not in the stem axon of MTN neurons.
Title: Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132337 (e-PCR)
- UniSTS:215620

D4Got133 (e-PCR)
- UniSTS:114086

BE107724 (e-PCR)
- UniSTS:247024

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 6

Names: RCK2; kv2; potassium channel, voltage gated shaker related subfamily A, member 6; potassium channel-Kv2; potassium voltage gated channel, shaker related subfamily, member 6; voltage-gated potassium channel subunit Kv1.6; voltage-gated potassium channel subunit Kv2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023954.2 → NP_076444.1 potassium voltage-gated channel subfamily A member 6

See identical proteins and their annotated locations for NP_076444.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P17659, P19025

UniProtKB/TrEMBL

A6ILW1, G3V8L6

Related

ENSRNOP00000071895.1, ENSRNOT00000080139.2

Conserved Domains (4) summary

smart00225
Location:43 → 126

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:260 → 469

Ion_trans; Ion transport protein

pfam02214
Location:43 → 132

BTB_2; BTB/POZ domain

pfam07885
Location:383 → 460

Ion_trans_2; Ion channel