U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LINC01128 long intergenic non-protein coding RNA 1128 [ Homo sapiens (human) ]

Gene ID: 643837, updated on 19-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
LINC01128provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1128provided by HGNC
Primary source
HGNC:HGNC:49377
See related
Ensembl:ENSG00000228794 AllianceGenome:HGNC:49377
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in heart (RPKM 8.4), fat (RPKM 5.1) and 25 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p36.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (827591..859446)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (256563..288416)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (762971..794826)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2 Neighboring gene family with sequence similarity 87 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1 Neighboring gene long intergenic non-protein coding RNA 115 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:772694-772873 Neighboring gene uncharacterized LOC107984850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:802261-802760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2 Neighboring gene family with sequence similarity 41 member C Neighboring gene tubulin beta 8 class VIII pseudogene 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LINC01128 facilitates the progression of pancreatic cancer through up-regulation of LDHA by targeting miR-561-5p. Zhong M, et al. Cancer Cell Int, 2022 Feb 22. PMID 35193567, Free PMC Article
  2. LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells. Zhao X, et al. Hypertens Pregnancy, 2021 May. PMID 33881945
  3. Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p. Zhang Q, et al. Folia Neuropathol, 2022. PMID 36382487
  4. LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/β-catenin signalling pathway. Yao Q, et al. J Cell Mol Med, 2020 Dec. PMID 33108067, Free PMC Article
  5. LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis. Hu Y, et al. BMC Cancer, 2019 Nov 28. PMID 31779593, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in beta2GPI/anti-beta2GPI-treated monocytes.
    Title: ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes.
  2. Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p.
    Title: Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p.
  3. LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells.
    Title: LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells.
  4. LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/beta-catenin signalling pathway.
    Title: LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/β-catenin signalling pathway.
  5. Long intergenic non-protein coding RNA 1128 (LINC01128) displays high expression in cervical cancer (CC) tissues. LINC01128 shortage reduces the expression of stratifin (SFN) at mRNA and protein levels. LINC01128 enhances cell proliferation, migration and invasion as well as inhibits cell apoptosis by binding with miR-383-5p and upregulating SFN.
    Title: LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Other Names

  • RP11-206L10.11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_047519.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AL669831, BC102012, CN361275, DR005973

  2. NR_047521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1.
    Source sequence(s)
    AL669831, BC042880, CN361275
    Related
    ENST00000445118.7

  3. NR_047523.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons compared to variant 1.
    Source sequence(s)
    AL669831, CN361275, DA780029

  4. NR_047524.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two consecutive internal exons compared to variant 1.
    Source sequence(s)
    AL669831, BC107481, CN361275

  5. NR_047525.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5'-most exon and lacks an internal exon, compared to variant 1.
    Source sequence(s)
    AL669831, DA223705

  6. NR_047526.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks a large portion of the 3' region and uses an alternate terminal exon, compared to variant 1.
    Source sequence(s)
    AI051839, AL669831, BX095144, CN361275

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    827591..859446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    256563..288416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015368.2: Suppressed sequence

    Description
    NR_015368.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NR_047520.1: Suppressed sequence

    Description
    NR_047520.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  3. NR_047522.1: Suppressed sequence

    Description
    NR_047522.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.