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Sirt3 sirtuin 3 [ Mus musculus (house mouse) ]

Gene ID: 64384, updated on 17-Oct-2021

Summary

Official Symbol
Sirt3provided by MGI
Official Full Name
sirtuin 3provided by MGI
Primary source
MGI:MGI:1927665
See related
Ensembl:ENSMUSG00000025486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l3; AI848213; 2310003L23Rik
Expression
Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt3 in Genome Data Viewer
Location:
7; 7 F4- F5
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140443576..140462222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140863663..140882309, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148049562..148068208, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 3 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene cytochrome c oxidase subunit 8B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-3
Names
NAD-dependent deacetylase sirtuin-3
SIR2-like protein 3
SIRT3L mitochondrial
mSIR2L3
mitochondrial protein lysine deacetylase
regulatory protein SIR2 homolog 3
silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
NP_001120823.1
NP_001171275.1
NP_071878.2
XP_006536285.1
XP_006536286.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127351.1NP_001120823.1  NAD-dependent protein deacetylase sirtuin-3 isoform 1

    See identical proteins and their annotated locations for NP_001120823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF299338, AF299339, BF681854, CT010402
    Consensus CDS
    CCDS21989.1
    UniProtKB/Swiss-Prot
    Q8R104
    UniProtKB/TrEMBL
    Q4FJK3
    Related
    ENSMUSP00000101663.4, ENSMUST00000106048.10
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_001177804.1NP_001171275.1  NAD-dependent protein deacetylase sirtuin-3 isoform 3

    See identical proteins and their annotated locations for NP_001171275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (2).
    Source sequence(s)
    AK075861, BF681854, CB953804
    UniProtKB/Swiss-Prot
    Q8R104
    Conserved Domains (1) summary
    cd01408
    Location:74308
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  3. NM_022433.2NP_071878.2  NAD-dependent protein deacetylase sirtuin-3 isoform 1

    See identical proteins and their annotated locations for NP_071878.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' exon and an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF299338, BF681854, CT010402
    Consensus CDS
    CCDS21989.1
    UniProtKB/Swiss-Prot
    Q8R104
    UniProtKB/TrEMBL
    Q4FJK3
    Related
    ENSMUSP00000026559.8, ENSMUST00000026559.14
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140443576..140462222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536222.5XP_006536285.1  NAD-dependent protein deacetylase sirtuin-3 isoform X1

    Conserved Domains (1) summary
    cl00195
    Location:74254
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_006536223.5XP_006536286.1  NAD-dependent protein deacetylase sirtuin-3 isoform X2

    See identical proteins and their annotated locations for XP_006536286.1

    Related
    ENSMUSP00000114247.2, ENSMUST00000137024.8
    Conserved Domains (1) summary
    cl00195
    Location:1177
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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