U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNG1F Zn regulated GTPase metalloprotein activator 1F [ Homo sapiens (human) ]

Gene ID: 644019, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZNG1Fprovided by HGNC
Official Full Name
Zn regulated GTPase metalloprotein activator 1Fprovided by HGNC
Primary source
HGNC:HGNC:31978
See related
Ensembl:ENSG00000215126 AllianceGenome:HGNC:31978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBWD6; CBWD7
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in kidney (RPKM 11.5), thyroid (RPKM 10.9) and 25 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9p11.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (41131309..41205735, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (42096131..42163687)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (69204538..69262546, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:69179459-69180234 Neighboring gene long intergenic non-protein coding RNA 3025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:69180235-69181009 Neighboring gene forkhead box D4 like 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:69261657-69262230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:69262231-69262802 Neighboring gene protein FRG1B-like Neighboring gene microRNA 4477a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
  2. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  3. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article
  4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
  5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ40320, FLJ60409, DKFZp686L07117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc-regulated GTPase metalloprotein activator 1F
Names
COBW domain containing 6
COBW domain containing 7
COBW domain-containing protein 6
cobalamin synthase W domain-containing protein 6
cobalamin synthetase W domain-containing protein 6
putative COBW domain-containing protein 7
putative cobalamin synthase W domain-containing protein 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085457.2 → NP_001078926.1  zinc-regulated GTPase metalloprotein activator 1F isoform 1

    See identical proteins and their annotated locations for NP_001078926.1

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Consensus CDS
    CCDS43827.1
    UniProtKB/Swiss-Prot
    Q4V339
    UniProtKB/TrEMBL
    A0A0A0MRU4
    Related
    ENSP00000366608.4, ENST00000377391.8
    Conserved Domains (3) summary
    COG0523
    Location:42 → 376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274 → 373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43 → 207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001386876.1 → NP_001373805.1  zinc-regulated GTPase metalloprotein activator 1F isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX255923
    UniProtKB/TrEMBL
    A0A0A0MRU4
    Conserved Domains (3) summary
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43 → 226
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:254 → 353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  3. NM_001386877.1 → NP_001373806.1  zinc-regulated GTPase metalloprotein activator 1F isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX255923
    UniProtKB/TrEMBL
    A0A087WWG3
    Conserved Domains (2) summary
    COG0523
    Location:42 → 327
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:19 → 62
    COG3044; Predicted ATPase of the ABC class [General function prediction only]

RNA

  1. NR_170339.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Related
    ENST00000494538.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    41131309..41205735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015028.2 → XP_016870517.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

  2. XM_047423722.1 → XP_047279678.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

  3. XM_047423720.1 → XP_047279676.1  zinc-regulated GTPase metalloprotein activator 1F isoform X6

  4. XM_017015025.2 → XP_016870514.1  zinc-regulated GTPase metalloprotein activator 1F isoform X5

    UniProtKB/TrEMBL
    A0A087WWG3

  5. XM_017015022.2 → XP_016870511.1  zinc-regulated GTPase metalloprotein activator 1F isoform X3

    UniProtKB/TrEMBL
    A0A087WWG3

  6. XM_017015023.2 → XP_016870512.1  zinc-regulated GTPase metalloprotein activator 1F isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRU4

  7. XM_017015021.2 → XP_016870510.1  zinc-regulated GTPase metalloprotein activator 1F isoform X2

    UniProtKB/TrEMBL
    A0A0A0MRU4

  8. XM_047423721.1 → XP_047279677.1  zinc-regulated GTPase metalloprotein activator 1F isoform X8

  9. XM_017015026.2 → XP_016870515.1  zinc-regulated GTPase metalloprotein activator 1F isoform X7

  10. XM_017015019.2 → XP_016870508.1  zinc-regulated GTPase metalloprotein activator 1F isoform X1

    UniProtKB/TrEMBL
    A0A0A0MRU4

  11. XM_017015036.2 → XP_016870525.1  zinc-regulated GTPase metalloprotein activator 1F isoform X20

    UniProtKB/TrEMBL
    A0A087WWG3

  12. XM_024447653.2 → XP_024303421.1  zinc-regulated GTPase metalloprotein activator 1F isoform X19

    UniProtKB/TrEMBL
    A0A087WWG3
    Conserved Domains (2) summary
    COG0523
    Location:42 → 347
    YejR; GTPase, G3E family [General function prediction only]
    cl26601
    Location:19 → 62
    ABC_ATPase; Predicted ATPase of the ABC class

  13. XM_017015035.2 → XP_016870524.1  zinc-regulated GTPase metalloprotein activator 1F isoform X18

    UniProtKB/TrEMBL
    A0A0A0MRU4, H0Y5V3
    Related
    ENSP00000401079.2, ENST00000456520.5

  14. XM_047423723.1 → XP_047279679.1  zinc-regulated GTPase metalloprotein activator 1F isoform X15

  15. XM_017015029.3 → XP_016870518.1  zinc-regulated GTPase metalloprotein activator 1F isoform X11

  16. XM_017015034.1 → XP_016870523.1  zinc-regulated GTPase metalloprotein activator 1F isoform X17

    UniProtKB/TrEMBL
    Q9HAZ6

  17. XM_017015033.1 → XP_016870522.1  zinc-regulated GTPase metalloprotein activator 1F isoform X16

  18. XM_024447652.1 → XP_024303420.1  zinc-regulated GTPase metalloprotein activator 1F isoform X14

    Conserved Domains (1) summary
    cl26870
    Location:20 → 208
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

  19. XM_017015031.1 → XP_016870520.1  zinc-regulated GTPase metalloprotein activator 1F isoform X13

  20. XM_017015030.2 → XP_016870519.1  zinc-regulated GTPase metalloprotein activator 1F isoform X12

  21. XM_017015027.2 → XP_016870516.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

RNA

  1. XR_001746362.2 RNA Sequence

  2. XR_001746359.2 RNA Sequence

  3. XR_007061337.1 RNA Sequence

  4. XR_001746361.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    42096131..42163687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363532.1 → XP_054219507.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

  2. XM_054363539.1 → XP_054219514.1  zinc-regulated GTPase metalloprotein activator 1F isoform X18

    UniProtKB/TrEMBL
    H0Y5V3

  3. XM_054363540.1 → XP_054219515.1  zinc-regulated GTPase metalloprotein activator 1F isoform X19

  4. XM_054363541.1 → XP_054219516.1  zinc-regulated GTPase metalloprotein activator 1F isoform X20

  5. XM_054363522.1 → XP_054219497.1  zinc-regulated GTPase metalloprotein activator 1F isoform X1

  6. XM_054363529.1 → XP_054219504.1  zinc-regulated GTPase metalloprotein activator 1F isoform X7

  7. XM_054363523.1 → XP_054219498.1  zinc-regulated GTPase metalloprotein activator 1F isoform X2

  8. XM_054363525.1 → XP_054219500.1  zinc-regulated GTPase metalloprotein activator 1F isoform X4

  9. XM_054363524.1 → XP_054219499.1  zinc-regulated GTPase metalloprotein activator 1F isoform X3

  10. XM_054363526.1 → XP_054219501.1  zinc-regulated GTPase metalloprotein activator 1F isoform X5

  11. XM_054363527.1 → XP_054219502.1  zinc-regulated GTPase metalloprotein activator 1F isoform X6

  12. XM_054363528.1 → XP_054219503.1  zinc-regulated GTPase metalloprotein activator 1F isoform X21

  13. XM_054363531.1 → XP_054219506.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

  14. XM_054363530.1 → XP_054219505.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

  15. XM_054363536.1 → XP_054219511.1  zinc-regulated GTPase metalloprotein activator 1F isoform X15

  16. XM_054363533.1 → XP_054219508.1  zinc-regulated GTPase metalloprotein activator 1F isoform X11

  17. XM_054363538.1 → XP_054219513.1  zinc-regulated GTPase metalloprotein activator 1F isoform X17

  18. XM_054363534.1 → XP_054219509.1  zinc-regulated GTPase metalloprotein activator 1F isoform X13

  19. XM_054363535.1 → XP_054219510.1  zinc-regulated GTPase metalloprotein activator 1F isoform X14

  20. XM_054363537.1 → XP_054219512.1  zinc-regulated GTPase metalloprotein activator 1F isoform X16

RNA

  1. XR_008488057.1 RNA Sequence

  2. XR_008488056.1 RNA Sequence

  3. XR_008488055.1 RNA Sequence

  4. XR_008488058.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V339.1 GenPept UniProtKB/Swiss-Prot:Q4V339

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous