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Gpr85 G protein-coupled receptor 85 [ Mus musculus (house mouse) ]

Gene ID: 64450, updated on 21-Apr-2024

Summary

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Official Symbol
Gpr85provided by MGI
Official Full Name
G protein-coupled receptor 85provided by MGI
Primary source
MGI:MGI:1927851
See related
Ensembl:ENSMUSG00000048216 AllianceGenome:MGI:1927851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900026B03Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within signal transduction. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal medulla; central nervous system; musculoskeletal system; peripheral nervous system ganglion; and trigeminal nerve. Orthologous to human GPR85 (G protein-coupled receptor 85). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 18.7), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A1; 6 5.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13834405..13839951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13834406..13839942, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15197 Neighboring gene base methyltransferase of 25S rRNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E2186 Neighboring gene STARR-positive B cell enhancer ABC_E4812 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13645143-13645444 Neighboring gene STARR-seq mESC enhancer starr_15198 Neighboring gene predicted gene, 53312 Neighboring gene STARR-seq mESC enhancer starr_15199 Neighboring gene STARR-seq mESC enhancer starr_15200 Neighboring gene STARR-seq mESC enhancer starr_15201 Neighboring gene STARR-seq mESC enhancer starr_15202 Neighboring gene STARR-seq mESC enhancer starr_15203 Neighboring gene STARR-seq mESC enhancer starr_15204 Neighboring gene RIKEN cDNA 1110019D14 gene Neighboring gene STARR-seq mESC enhancer starr_15205 Neighboring gene small integral membrane protein 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain. Sakai A, et al. Genes Cells, 2022 May. PMID 35194900
  2. SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. Chen Q, et al. Eur J Neurosci, 2012 Sep. PMID 22697179, Free PMC Article
  3. Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Ito J, et al. Cell Tissue Res, 2009 Nov. PMID 19763624
  4. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Lattin JE, et al. Immunome Res, 2008 Apr 29. PMID 18442421, Free PMC Article
  5. Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex. Hellebrand S, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018813

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.
    Title: Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.
  2. The results indicate that SREB2 is a negative regulator of adult neurogenesis and consequential cognitive functions.
    Title: SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory.
  3. Theses data implicate SREB2 as a potential risk factor for psychiatric disorders.
    Title: The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761L08121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 85
Names
super conserved receptor expressed in brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330666.1 → NP_001317595.1  probable G-protein coupled receptor 85

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001330667.1 → NP_001317596.1  probable G-protein coupled receptor 85

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022, CF738797
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_145066.5 → NP_659503.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_659503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000053837.8, ENSMUST00000060442.14
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    13834405..13839951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152258.1 → XP_036008151.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000111154.2, ENSMUST00000115491.2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017321705.3 → XP_017177194.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_030255527.2 → XP_030111387.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000111155.2, ENSMUST00000115492.2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_011241079.4 → XP_011239381.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_011239381.1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_030255529.2 → XP_030111389.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_030255528.2 → XP_030111388.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_030255530.2 → XP_030111390.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60894.1 GenPept UniProtKB/Swiss-Prot:P60894

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