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Dip2a disco interacting protein 2 homolog A [ Mus musculus (house mouse) ]

Gene ID: 64451, updated on 21-Apr-2024

Summary

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Official Symbol
Dip2aprovided by MGI
Official Full Name
disco interacting protein 2 homolog Aprovided by MGI
Primary source
MGI:MGI:2385920
See related
Ensembl:ENSMUSG00000020231 AllianceGenome:MGI:2385920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dip2; mKIAA0184; Kiaa0184-hp; 4931420H10Rik
Summary
Predicted to enable acetate-CoA ligase activity. Involved in acetyl-CoA biosynthetic process; dendritic spine morphogenesis; and positive regulation of peptidyl-lysine acetylation. Located in dendritic spine and mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DIP2A (disco interacting protein 2 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 15.1), colon adult (RPKM 14.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 38.76 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76098581..76181194, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76263034..76345360, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27175 Neighboring gene microRNA 678 Neighboring gene protein arginine N-methyltransferase 2 Neighboring gene S100 protein, beta polypeptide, neural Neighboring gene predicted gene, 40699 Neighboring gene STARR-seq mESC enhancer starr_27177 Neighboring gene pericentrin (kendrin) Neighboring gene RIKEN cDNA 1700094J05 gene Neighboring gene STARR-seq mESC enhancer starr_27178 Neighboring gene STARR-seq mESC enhancer starr_27179 Neighboring gene predicted gene 9744

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice. Ma J, et al. Cereb Cortex, 2023 Apr 4. PMID 36227200
  2. A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice. Zhang Y, et al. Int Microbiol, 2022 May. PMID 34562157
  3. DIP2A is involved in SOD-mediated antioxidative reactions in murine brain. Bai LL, et al. Free Radic Biol Med, 2021 May 20. PMID 33781892
  4. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition. Kinatukara P, et al. Transgenic Res, 2020 Dec. PMID 33184751
  5. Functional prediction and characterization of Dip2 gene in mice. Ma J, et al. Cell Biol Int, 2019 Apr. PMID 30672040

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
    Title: Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.
  2. A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
    Title: A pilot study to investigate the alteration of gut microbial profile in Dip2a knockout mice.
  3. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
    Title: Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition.
  4. DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
    Title: DIP2A is involved in SOD-mediated antioxidative reactions in murine brain.
  5. Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
    Title: Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
  6. Genome wide transcriptional analysis using wild type and Dip2a knockout mice in brain and lung at embryonic day 19.5 (E19.5) provided a genetic basis of molecular function of these genes.
    Title: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disco-interacting protein 2 homolog A
Names
DIP2 disco-interacting protein 2 homolog A
DIP2 homolog A
NP_001074888.2
XP_006514002.1
XP_006514003.1
XP_006514004.1
XP_030101068.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081419.2 → NP_001074888.2  disco-interacting protein 2 homolog A

    Status: VALIDATED

    Source sequence(s)
    AB093213, AI845124, AK050040, AK052899
    Consensus CDS
    CCDS35944.2
    UniProtKB/TrEMBL
    D3Z7D3, F8WI56
    Related
    ENSMUSP00000043710.8, ENSMUST00000036033.14
    Conserved Domains (4) summary
    COG0318
    Location:321 → 914
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:982 → 1456
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:9 → 122
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:347 → 911
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76098581..76181194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513941.5 → XP_006514004.1  disco-interacting protein 2 homolog A isoform X3

    UniProtKB/TrEMBL
    D3Z7D3
    Conserved Domains (2) summary
    cd05905
    Location:918 → 1492
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:10 → 122
    DMAP_binding; DMAP1-binding Domain

  2. XM_006513939.5 → XP_006514002.1  disco-interacting protein 2 homolog A isoform X1

    UniProtKB/TrEMBL
    D3Z7D3
    Conserved Domains (2) summary
    cd05905
    Location:994 → 1568
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:10 → 122
    DMAP_binding; DMAP1-binding Domain

  3. XM_006513940.5 → XP_006514003.1  disco-interacting protein 2 homolog A isoform X2

    UniProtKB/Swiss-Prot
    E0CXM7, Q8BWT5, Q8CHI0
    Related
    ENSMUSP00000125184.2, ENSMUST00000160048.8
    Conserved Domains (2) summary
    cd05905
    Location:955 → 1529
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:10 → 83
    DMAP_binding; DMAP1-binding Domain

  4. XM_030245208.2 → XP_030101068.1  disco-interacting protein 2 homolog A isoform X4

    Conserved Domains (2) summary
    pfam06464
    Location:10 → 122
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:266 → 756
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_001779571.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWT5.3 GenPept UniProtKB/Swiss-Prot:Q8BWT5

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