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Cnbp CCHC-type zinc finger, nucleic acid binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 64530, updated on 11-Apr-2024

Summary

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Official Symbol
Cnbpprovided by RGD
Official Full Name
CCHC-type zinc finger, nucleic acid binding proteinprovided by RGD
Primary source
RGD:621807
See related
Ensembl:ENSRNOG00000010239 AllianceGenome:RGD:621807
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf9; Cnbp1
Summary
Enables single-stranded DNA binding activity and single-stranded RNA binding activity. Predicted to be involved in G-quadruplex DNA formation; positive regulation of cell population proliferation; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 3356.9), Heart (RPKM 2167.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121860102..121868976, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120302768..120311694, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119747890..119756787, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAB43, member RAS oncogene family Neighboring gene ISY1 splicing factor homolog Neighboring gene glutathione S-transferase alpha 4, pseudogene 4 Neighboring gene uncharacterized LOC134486609

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of rat cellular nucleic acid binding protein (CNBP) cDNA. Yasuda J, et al. DNA Res, 1995. PMID 7788528
  2. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription. Chen S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23774591
  3. The myotonic dystrophy type 2 (DM2) gene product zinc finger protein 9 (ZNF9) is associated with sarcomeres and normally localized in DM2 patients' muscles. Massa R, et al. Neuropathol Appl Neurobiol, 2010 Jun. PMID 20102514
  4. Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene. Shimizu K, et al. Gene, 2003 Mar 27. PMID 12706888
  5. Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy. Chen W, et al. J Mol Biol, 2007 Apr 20. PMID 17335846

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles
    Title: The myotonic dystrophy type 2 (DM2) gene product zinc finger protein 9 (ZNF9) is associated with sarcomeres and normally localized in DM2 patients' muscles.
  2. Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice.
    Title: Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-quadruplex DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G-quadruplex DNA formation IEA
Inferred from Electronic Annotation
more info
  
involved_in G-quadruplex DNA formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CCHC-type zinc finger nucleic acid binding protein
Names
cellular nucleic acid binding protein 1
cellular nucleic acid-binding protein
zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022598.1 → NP_072120.1  CCHC-type zinc finger nucleic acid binding protein

    See identical proteins and their annotated locations for NP_072120.1

    Status: PROVISIONAL

    Source sequence(s)
    D45254
    UniProtKB/Swiss-Prot
    P62634, Q5QJQ8
    UniProtKB/TrEMBL
    A6IB27
    Conserved Domains (1) summary
    PTZ00368
    Location:54 → 171
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    121860102..121868976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236854.5 → XP_006236916.1  CCHC-type zinc finger nucleic acid binding protein isoform X3

    See identical proteins and their annotated locations for XP_006236916.1

    UniProtKB/TrEMBL
    A6IB26
    Conserved Domains (1) summary
    PTZ00368
    Location:47 → 164
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  2. XM_017592879.3 → XP_017448368.1  CCHC-type zinc finger nucleic acid binding protein isoform X2

    Conserved Domains (1) summary
    PTZ00368
    Location:47 → 165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  3. XM_017592878.3 → XP_017448367.1  CCHC-type zinc finger nucleic acid binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q6G7
    Related
    ENSRNOP00000013884.6
    Conserved Domains (1) summary
    PTZ00368
    Location:54 → 172
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62634.1 GenPept UniProtKB/Swiss-Prot:P62634

Gene LinkOut

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