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Mpeg1 macrophage expressed 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64552, updated on 30-Mar-2024

Summary

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Official Symbol
Mpeg1provided by RGD
Official Full Name
macrophage expressed 1provided by RGD
Primary source
RGD:69275
See related
Ensembl:ENSRNOG00000063244 AllianceGenome:RGD:69275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P-2; Mpg-1
Summary
Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of other organism. Predicted to be located in phagocytic vesicle. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 829.7), Liver (RPKM 558.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1q43
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (218876848..218881364)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209452176..209456692)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228724559..228729054)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily A member 3 Neighboring gene pore forming protein-like Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene FAM111A pseudogene Neighboring gene FAM111 trypsin like peptidase A like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection. Strbo N, et al. Exp Dermatol, 2019 Mar. PMID 30609079, Free PMC Article
  2. Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. McCormack RM, et al. Elife, 2015 Sep 24. PMID 26402460, Free PMC Article
  3. Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. Fields KA, et al. Infect Immun, 2013 Aug. PMID 23753625, Free PMC Article
  4. Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. McCormack R, et al. J Innate Immun, 2013. PMID 23257510, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables pore-forming activity ISO
Inferred from Sequence Orthology
more info
  
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
enables wide pore channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in antibacterial innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic cell antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endolysosome ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagocytic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagolysosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagolysosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
macrophage-expressed gene 1 protein
Names
perforin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305460.1 → NP_001292389.1  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_001292389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI511268, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9WV57
    UniProtKB/TrEMBL
    A0A8I6AL73, A6I0D5
    Conserved Domains (1) summary
    pfam01823
    Location:132 → 348
    MACPF; MAC/Perforin domain

  2. NM_022617.2 → NP_072139.2  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_072139.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI511268, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9WV57
    UniProtKB/TrEMBL
    A0A8I6AL73, A6I0D5
    Conserved Domains (1) summary
    pfam01823
    Location:132 → 348
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    218876848..218881364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760261.2 → XP_008758483.1  macrophage-expressed gene 1 protein isoform X1

    See identical proteins and their annotated locations for XP_008758483.1

    UniProtKB/Swiss-Prot
    Q9WV57
    UniProtKB/TrEMBL
    A0A8I6AL73, A6I0D5
    Related
    ENSRNOP00000095321.1, ENSRNOT00000094170.1
    Conserved Domains (1) summary
    pfam01823
    Location:132 → 348
    MACPF; MAC/Perforin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV57.2 GenPept UniProtKB/Swiss-Prot:Q9WV57

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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