dcn decorin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dcnprovided by ZNC
Official Full Name: decorinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010102-1
See related: Ensembl:ENSDARG00000012066 AllianceGenome:ZFIN:ZDB-GENE-010102-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DC
Summary: Predicted to enable collagen binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Acts upstream of or within cartilage development; chondroitin sulfate proteoglycan metabolic process; and convergent extension involved in axis elongation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranial cartilage; epidermis; nervous system; pericardial region; and periderm. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (16368762..16406724, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (16379786..16417748, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decorin has a critical role during early embryogenesis
Title: A central role for decorin during vertebrate convergent extension.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: decorin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131697.1 → NP_571772.1 decorin precursor

See identical proteins and their annotated locations for NP_571772.1

Status: PROVISIONAL

Source sequence(s)

BC044206

UniProtKB/TrEMBL

Q803T1

Related

ENSDARP00000025940.8, ENSDART00000013085.9

Conserved Domains (4) summary

smart00013
Location:66 → 97

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:233 → 326

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:74 → 94

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:233 → 293

LRR_8; Leucine rich repeat